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The Guizhi Gancao Decoction Attenuates Myocardial Ischemia-Reperfusion Injury by Suppressing Inflammation and Cardiomyocyte Apoptosis
Joint Authors
Gao, Yuan
Song, Ge
Cao, Ying-Jie
Yan, Kui-Po
Li, Bin
Zhu, Xin-Feng
Wang, You-Ping
Xing, Zuo-Ying
Cui, Lin
Wang, Xiao-Xiao
Zhu, Ming-Jun
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-01-21
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Guizhi Gancao Decoction (GGD) is a well-known traditional Chinese herbal medicine for the treatment of various cardiovascular diseases, such as myocardial ischemia-reperfusion (I/R) injury and arrhythmia.
However, the mechanism by which GGD contributes to the amelioration of cardiac injury remains unclear.
The aim of this study was to investigate the potential protective role of GGD against myocardial I/R injury and its possible mechanism.
Consistent with the effect of the positive drug (Trimetazidine, TMZ), we subsequently validated that GGD could ameliorate myocardial I/R injury as evidenced by histopathological examination and triphenyltetrazolium chloride (TTC) staining.
Moreover, terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assay demonstrated that GGD suppressed myocardial apoptosis, which may be related to the upregulation of Bcl-2, PPARα, and PPARγ and downregulation of Bax, caspase-3, and caspase-9.
Pretreatment with GGD attenuated the levels of proinflammatory cytokines including tumor necrosis factor-α (TNF-α), interleukin- (IL-) 6, and IL-1β in serum by inhibiting Toll-like receptor 4 (TLR4)/NF-κB signaling pathway.
These results indicated that GGD exhibits cardioprotective effects on myocardial I/R injury through inhibition of the TLR4/NF-κB signaling pathway, which led to reduced inflammatory response and the subsequent cardiomyocyte apoptosis.
American Psychological Association (APA)
Gao, Yuan& Song, Ge& Cao, Ying-Jie& Yan, Kui-Po& Li, Bin& Zhu, Xin-Feng…[et al.]. 2019. The Guizhi Gancao Decoction Attenuates Myocardial Ischemia-Reperfusion Injury by Suppressing Inflammation and Cardiomyocyte Apoptosis. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1148794
Modern Language Association (MLA)
Gao, Yuan…[et al.]. The Guizhi Gancao Decoction Attenuates Myocardial Ischemia-Reperfusion Injury by Suppressing Inflammation and Cardiomyocyte Apoptosis. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1148794
American Medical Association (AMA)
Gao, Yuan& Song, Ge& Cao, Ying-Jie& Yan, Kui-Po& Li, Bin& Zhu, Xin-Feng…[et al.]. The Guizhi Gancao Decoction Attenuates Myocardial Ischemia-Reperfusion Injury by Suppressing Inflammation and Cardiomyocyte Apoptosis. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1148794
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1148794