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Galactose-Deficient IgA1 Deposits in Clear Cell Renal Cell Carcinoma-Related Henoch–Schönlein Purpura Nephritis
Joint Authors
Kim, Youngki
Li, Faqian
Zhao, Yuhong
Junghare, Milind
Vakil, Viral
Su, Xuesong
Bu, Lihong
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-08-24
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Recent studies suggest that galactose-deficient IgA1 (Gd-IgA1) plays a role in the pathogenesis of primary IgA nephropathy (IgAN) and Henoch–Schönlein purpura nephritis (HSPN).
Furthermore, immunostaining of KM55, an antibody that identifies Gd-IgA1, may be helpful to differentiate primary IgAN and HSPN from secondary causes of glomerular IgA deposition.
We report sequential kidney biopsies of a malignancy-associated HSPN, showing intense glomerular mesangial IgA deposition at the initial kidney biopsy and dramatic decrease in disappearance of glomerular deposits after tumor removal.
We demonstrate that the glomerular IgA deposition contains Gd-IgA1, detected by immunostaining of KM55, with similar distribution and intensity to IgA.
This suggests that renal Gd-IgA1 deposition may play a role in the pathogenesis of malignancy-associated HSPN.
American Psychological Association (APA)
Zhao, Yuhong& Kim, Youngki& Junghare, Milind& Vakil, Viral& Su, Xuesong& Li, Faqian…[et al.]. 2020. Galactose-Deficient IgA1 Deposits in Clear Cell Renal Cell Carcinoma-Related Henoch–Schönlein Purpura Nephritis. Case Reports in Nephrology،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1148811
Modern Language Association (MLA)
Zhao, Yuhong…[et al.]. Galactose-Deficient IgA1 Deposits in Clear Cell Renal Cell Carcinoma-Related Henoch–Schönlein Purpura Nephritis. Case Reports in Nephrology No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1148811
American Medical Association (AMA)
Zhao, Yuhong& Kim, Youngki& Junghare, Milind& Vakil, Viral& Su, Xuesong& Li, Faqian…[et al.]. Galactose-Deficient IgA1 Deposits in Clear Cell Renal Cell Carcinoma-Related Henoch–Schönlein Purpura Nephritis. Case Reports in Nephrology. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1148811
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1148811