Postradiation Histiocytic Sarcoma in the Setting of Muir-Torre Syndrome
Joint Authors
Pavlidakey, Peter
Baumgartner, Erin
Ullman, David
Jones, Jeffrey Adam
Fasciano, Danielle
Atherton, Daniel S.
Peker, Deniz
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-04-24
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Hereditary nonpolyposis colorectal carcinoma (HNPCC) is an autosomal dominant genetic disorder characterized by a predisposition towards colorectal carcinoma and other extracolonic neoplasms.
Histiocytic sarcoma (HS) is a very rare hematologic neoplasm characterized by a malignant proliferation of cells with histiocytic differentiation.
We present the case of a 62-year-old male with previous diagnosis of MTS who presented with metastatic colorectal adenocarcinoma, bilateral papillary renal cell carcinoma, and a new squamous cell carcinoma of the scalp, treated with resection and adjuvant radiation therapy.
After reconstructive surgery for his scalp resection, the patient developed a persistent nonhealing skin defect.
A punch biopsy of this nonhealing skin defect and subsequent immunohistochemistry revealed neoplastic histiocytic cells restricted to the epidermis and underlying dermis.
The diagnosis of cutaneous histiocytic sarcoma was then rendered.
Histiocytic sarcoma is an exceptionally rare malignancy.
Consequently, there is no universally agreed upon management protocol for this malignancy.
The patient was admitted to hospice and treated with palliative radiation.
This case demonstrates the need for awareness of the risk of secondary malignancies in cancer patients in order to facilitate early surgical intervention and optimal treatment.
American Psychological Association (APA)
Baumgartner, Erin& Ullman, David& Jones, Jeffrey Adam& Fasciano, Danielle& Atherton, Daniel S.& Pavlidakey, Peter…[et al.]. 2018. Postradiation Histiocytic Sarcoma in the Setting of Muir-Torre Syndrome. Case Reports in Pathology،Vol. 2018, no. 2018, pp.1-4.
https://search.emarefa.net/detail/BIM-1148819
Modern Language Association (MLA)
Baumgartner, Erin…[et al.]. Postradiation Histiocytic Sarcoma in the Setting of Muir-Torre Syndrome. Case Reports in Pathology No. 2018 (2018), pp.1-4.
https://search.emarefa.net/detail/BIM-1148819
American Medical Association (AMA)
Baumgartner, Erin& Ullman, David& Jones, Jeffrey Adam& Fasciano, Danielle& Atherton, Daniel S.& Pavlidakey, Peter…[et al.]. Postradiation Histiocytic Sarcoma in the Setting of Muir-Torre Syndrome. Case Reports in Pathology. 2018. Vol. 2018, no. 2018, pp.1-4.
https://search.emarefa.net/detail/BIM-1148819
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1148819