Langerhans Cell Histiocytosis: A Diagnostic Challenge in the Oral Cavity
Joint Authors
Salim, Ozan
Altay, Mehmet Ali
Sindel, Alper
Özalp, Öznur
Kocabalkan, Burak
Özbudak, İrem Hicran
Erdem, Ramazan
Baur, Dale A.
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-10-24
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
Langerhans cell histiocytosis (LCH) is a rare disorder of the reticuloendothelial system with unknown etiology.
This report aims to present a case of LCH with diffuse involvement of the oral cavity and to raise awareness of the distinguishing features of this diagnostically challenging entity.
Case Report.
A 26-year-old male patient presented with complaints of teeth mobility, intense pain, and difficulty in chewing.
Intraoral and radiological examinations revealed generalized gingival hyperplasia and severe teeth mobility with widespread alveolar bone loss.
Periodontal therapy was performed with no significant improvement.
An incisional biopsy revealed Langerhans cells and positive reaction to S-100 and CD1, and the patient was diagnosed with LCH.
The patient underwent systemic chemotherapy with vinca alkaloids and corticosteroids.
Regression of gingival lesions, as well as significant decrease in mobility of the remaining teeth and severity of pain, was achieved during 12 months of follow-up.
Conclusion.
The rarity and variable system involvement of LCH necessitate a multidisciplinary approach be carried out for accurate diagnosis, effective treatment, and an uneventful follow-up.
Awareness of oral manifestations of LCH may aid clinicians greatly in reducing morbidity and mortality associated with this debilitating condition.
American Psychological Association (APA)
Altay, Mehmet Ali& Sindel, Alper& Özalp, Öznur& Kocabalkan, Burak& Özbudak, İrem Hicran& Erdem, Ramazan…[et al.]. 2017. Langerhans Cell Histiocytosis: A Diagnostic Challenge in the Oral Cavity. Case Reports in Pathology،Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1148826
Modern Language Association (MLA)
Altay, Mehmet Ali…[et al.]. Langerhans Cell Histiocytosis: A Diagnostic Challenge in the Oral Cavity. Case Reports in Pathology No. 2017 (2017), pp.1-6.
https://search.emarefa.net/detail/BIM-1148826
American Medical Association (AMA)
Altay, Mehmet Ali& Sindel, Alper& Özalp, Öznur& Kocabalkan, Burak& Özbudak, İrem Hicran& Erdem, Ramazan…[et al.]. Langerhans Cell Histiocytosis: A Diagnostic Challenge in the Oral Cavity. Case Reports in Pathology. 2017. Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1148826
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1148826