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A 4-Week Repeated Oral Dose Toxicity Study of Ssanghwa-Tang in Crl:CD Sprague Dawley Rats
Joint Authors
Shin, Hyeun-Kyoo
Seo, Chang-Seob
Yoo, Sae-Rom
Han, Su-Cheol
Ha, Hyekyung
Lee, Mee-Young
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-05-16
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Ssanghwa-tang (SHT), a traditional herbal formula, has been widely used to recover fatigue or consumptive disease after an illness.
Along with much attention to herbal formula, the concerns about the safety and toxicity have arisen.
To establish the safety information, SHT was administrated in Crl:CD Sprague Dawley rats at a daily dose of 0, 1000, 2000, and 5000 mg/kg for 4 weeks.
During the test periods, we examined the mortality, clinical observation, body weight change, food consumption, organ weights, hematology, serum biochemistry, and urinalysis parameters.
No changes of mortality and necropsy findings occurred in any of the groups during the experimental period.
In either sex of rats treated with SHT at 5000 mg/kg/day, changes were observed in food intake, reticulocyte, total bilirubin, some urinalysis parameters, and relative organ weights.
The results indicated that SHT did not induce toxic effects at a dose level up to 2000 mg/kg in rats.
This dosage was considered no observed adverse effect level (NOAEL) and was appropriate for a 13-week subchronic toxicity study.
American Psychological Association (APA)
Yoo, Sae-Rom& Ha, Hyekyung& Lee, Mee-Young& Shin, Hyeun-Kyoo& Han, Su-Cheol& Seo, Chang-Seob. 2019. A 4-Week Repeated Oral Dose Toxicity Study of Ssanghwa-Tang in Crl:CD Sprague Dawley Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1148827
Modern Language Association (MLA)
Yoo, Sae-Rom…[et al.]. A 4-Week Repeated Oral Dose Toxicity Study of Ssanghwa-Tang in Crl:CD Sprague Dawley Rats. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1148827
American Medical Association (AMA)
Yoo, Sae-Rom& Ha, Hyekyung& Lee, Mee-Young& Shin, Hyeun-Kyoo& Han, Su-Cheol& Seo, Chang-Seob. A 4-Week Repeated Oral Dose Toxicity Study of Ssanghwa-Tang in Crl:CD Sprague Dawley Rats. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1148827
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1148827