Anxiolytic-Like Effects of Bergamot Essential Oil Are Insensitive to Flumazenil in Rats
Joint Authors
Corasaniti, Maria Tiziana
Bagetta, Giacinto
Morrone, Luigi Antonio
Tonin, Paolo
Rombolà, Laura
Scuteri, Damiana
Adornetto, Annagrazia
Straface, Marilisa
Sakurada, Tsukasa
Sakurada, Shinobu
Mizoguchi, Hirokazu
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-08-14
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Anxiety disorders are one of the most common mental disorders, and benzodiazepines (BDZs), acting on gamma-aminobutyric acid type A (GABA-A) receptor complex, represent the most common antianxiety medications in the world.
However, chronic BDZ use elicits several adverse reactions.
Reportedly, aromatherapy is safer for the management of anxiety.
Bergamot essential oil (BEO) extracted from Citrus bergamia Risso et Poiteau fruit, like other essential oils, is widely used in aromatherapy to relieve symptoms of stress-induced anxiety.
Interestingly, preclinical data indicate that BEO induces anxiolytic-like/relaxant effects in animal behavioural tasks not superimposable to those of benzodiazepine diazepam.
To better elucidate the involvement of GABAergic transmission, the present study examines the effects of pretreatment with flumazenil (FLZ), a benzodiazepine site antagonist, on BEO effects using open-field task (OFT) in rats.
The data yielded show that FLZ does not significantly affect behavioural effects of the phytocomplex.
These results demonstrate the lack of overlapping between BEO and BDZ behavioural effects, contributing to the characterization of the neurobiological profile of the essential oil for its rational use in aromatherapy.
American Psychological Association (APA)
Rombolà, Laura& Scuteri, Damiana& Adornetto, Annagrazia& Straface, Marilisa& Sakurada, Tsukasa& Sakurada, Shinobu…[et al.]. 2019. Anxiolytic-Like Effects of Bergamot Essential Oil Are Insensitive to Flumazenil in Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1148833
Modern Language Association (MLA)
Rombolà, Laura…[et al.]. Anxiolytic-Like Effects of Bergamot Essential Oil Are Insensitive to Flumazenil in Rats. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-6.
https://search.emarefa.net/detail/BIM-1148833
American Medical Association (AMA)
Rombolà, Laura& Scuteri, Damiana& Adornetto, Annagrazia& Straface, Marilisa& Sakurada, Tsukasa& Sakurada, Shinobu…[et al.]. Anxiolytic-Like Effects of Bergamot Essential Oil Are Insensitive to Flumazenil in Rats. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1148833
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1148833