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The Association of TNF-Alpha Inhibitors and Development of IgA Nephropathy in Patients with Rheumatoid Arthritis and Diabetes
Joint Authors
Premužić, Vedran
Padjen, Ivan
Cerovec, Mislav
Ćorić, Marijana
Jelaković, Bojan
Anić, Branimir
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-04-21
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
IgA nephropathy (IgAN) is a rather uncommon complication of TNF-alpha inhibition with a range of findings such as asymptomatic microscopic/macroscopic hematuria or different degrees of proteinuria and could progress to end-stage renal disease.
We are reporting three patients with longstanding rheumatoid arthritis (RA), which developed IgAN while receiving TNF-alpha inhibitors.
All off our three patients had RA, which lasted 2–4 years, and none of them had a prior history of chronic kidney disease.
Two patients were treated with adalimumab while one patient was treated with golimumab.
Discontinuation of anti-TNF-alpha therapy and initiation of immunosuppressive therapy led to improvement in serologic abnormalities and renal function in two patients, while the third patient’s 24-hour proteinuria was only partially reduced, which supports previous reports on TNF-alpha inhibitor induced autoimmunity.
Two of our patients had previously been diagnosed with type 2 diabetes mellitus while the third patient developed diabetes years after the onset of IgAN.
This is in line with the previously described association of IgAN and diabetes mellitus.
To our best knowledge, this is the first report to analyze the development of IgAN as a potential consequence of anti-TNF-alpha therapy and its possible association with pretreatment or posttreatment diabetes.
American Psychological Association (APA)
Premužić, Vedran& Padjen, Ivan& Cerovec, Mislav& Ćorić, Marijana& Jelaković, Bojan& Anić, Branimir. 2020. The Association of TNF-Alpha Inhibitors and Development of IgA Nephropathy in Patients with Rheumatoid Arthritis and Diabetes. Case Reports in Nephrology،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1148847
Modern Language Association (MLA)
Premužić, Vedran…[et al.]. The Association of TNF-Alpha Inhibitors and Development of IgA Nephropathy in Patients with Rheumatoid Arthritis and Diabetes. Case Reports in Nephrology No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1148847
American Medical Association (AMA)
Premužić, Vedran& Padjen, Ivan& Cerovec, Mislav& Ćorić, Marijana& Jelaković, Bojan& Anić, Branimir. The Association of TNF-Alpha Inhibitors and Development of IgA Nephropathy in Patients with Rheumatoid Arthritis and Diabetes. Case Reports in Nephrology. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1148847
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1148847