Bilateral Neurofibromas of the Nipple-Areolar Complex: A Case Report and Approach to Diagnosis
Joint Authors
Hero, Emily
Carey, Martyn
Hero, Isabelle
Shaaban, Abeer M.
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-09-06
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Neurofibromatosis type 1 is an autosomal dominant condition which can manifest as multiple neurofibromas within subcutaneous tissue.
Neurofibromas of the breast are rare and most often encountered on the nipple-areolar complexes.
A 33-year-old woman presented with large, bilateral, fleshy, skin tags of the nipple-areolar complexes.
She underwent bilateral diagnostic excision of the lesions and macroscopically, both nipple specimens displaying polypoid lesions.
Histological examination showed bilateral neurofibromas comprising skin with underlying dermal proliferation of bland spindle shaped cells with wavy nuclei.
Immunohistochemistry confirmed the spindle cell proliferation to be neural in origin; positive for S100 and neurofilament and negative for cytokeratins.
This was associated with florid smooth muscle proliferation.
This case demonstrates a rare presentation of nipple-areolar neurofibroma occurring within the skin and nipple parenchyma.
Our report considers the differential diagnoses of spindle cell proliferation within the dermis and subcutis of the breast and also other deeper breast spindle cell lesions that may involve the nipple.
It aims to provide an approach to diagnosing these lesions examining the literature surrounding breast neurofibromas.
American Psychological Association (APA)
Hero, Emily& Carey, Martyn& Hero, Isabelle& Shaaban, Abeer M.. 2018. Bilateral Neurofibromas of the Nipple-Areolar Complex: A Case Report and Approach to Diagnosis. Case Reports in Pathology،Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1148851
Modern Language Association (MLA)
Hero, Emily…[et al.]. Bilateral Neurofibromas of the Nipple-Areolar Complex: A Case Report and Approach to Diagnosis. Case Reports in Pathology No. 2018 (2018), pp.1-5.
https://search.emarefa.net/detail/BIM-1148851
American Medical Association (AMA)
Hero, Emily& Carey, Martyn& Hero, Isabelle& Shaaban, Abeer M.. Bilateral Neurofibromas of the Nipple-Areolar Complex: A Case Report and Approach to Diagnosis. Case Reports in Pathology. 2018. Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1148851
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1148851