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Paravertebral Well-Differentiated Liposarcoma with Low-Grade Osteosarcomatous Component: Case Report with 11-Year Follow-Up, Radiological, Pathological, and Genetic Data, and Literature Review
Joint Authors
Dufour, Henry
de Pinieux, Gonzague
Fuentes, Stéphane
Macagno, Nicolas
Maues de Paula, André
Salas, Sébastien
Mattéi, Jean-Camille
Dupuis, Charlotte
Appay, Romain
Aurias, Alain
Figarella-Branger, Dominique
Bouvier, Corinne
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-03-09
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Despite being one of the most frequent soft-tissue sarcomas, well-differentiated liposarcoma has never been reported near the spine.
The authors present the case of a 67-year-old man with progressive history of back pain.
Physical examination revealed a mass located within the right paravertebral muscles.
MR and CT imaging showed a heavily ossified central mass surrounded by a peripheral fatty component.
No connection with the underlying bone was detected on imagery and during surgery.
After surgical resection, histopathological examination revealed a tumor harboring combined features of well-differentiated liposarcoma and low-grade osteosarcoma.
Tumor cells displayed overexpression of MDM2, CDK4, and P16 by immunohistochemistry and CGH revealed amplification of 12q13-15 as the only genetic imbalance.
MDM2 FISH analysis was performed but was inconclusive.
The pathological, immunohistochemical, and genetic features, the differential diagnoses, and the therapeutic management of this unusual tumor are discussed.
No complementary treatment was performed initially.
Following first treatment, two recurrences occurred 6 and 9 years later, both displaying histological features similar to the first occurrence.
Radiotherapy was started after the second recurrence.
Follow-up shows no evidence of disease 11 years after initial diagnosis.
This case was unusual due to the paravertebral location of the tumor and its divergent differentiation.
American Psychological Association (APA)
Macagno, Nicolas& Fuentes, Stéphane& de Pinieux, Gonzague& Maues de Paula, André& Salas, Sébastien& Mattéi, Jean-Camille…[et al.]. 2017. Paravertebral Well-Differentiated Liposarcoma with Low-Grade Osteosarcomatous Component: Case Report with 11-Year Follow-Up, Radiological, Pathological, and Genetic Data, and Literature Review. Case Reports in Pathology،Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1148860
Modern Language Association (MLA)
Macagno, Nicolas…[et al.]. Paravertebral Well-Differentiated Liposarcoma with Low-Grade Osteosarcomatous Component: Case Report with 11-Year Follow-Up, Radiological, Pathological, and Genetic Data, and Literature Review. Case Reports in Pathology No. 2017 (2017), pp.1-6.
https://search.emarefa.net/detail/BIM-1148860
American Medical Association (AMA)
Macagno, Nicolas& Fuentes, Stéphane& de Pinieux, Gonzague& Maues de Paula, André& Salas, Sébastien& Mattéi, Jean-Camille…[et al.]. Paravertebral Well-Differentiated Liposarcoma with Low-Grade Osteosarcomatous Component: Case Report with 11-Year Follow-Up, Radiological, Pathological, and Genetic Data, and Literature Review. Case Reports in Pathology. 2017. Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1148860
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1148860