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Protective Effects of Evodiamine against LPS-Induced Acute Kidney Injury through Regulation of ROS-NF-κB-Mediated Inflammation
Joint Authors
Shi, Yan
Hua, Qiuju
Li, Na
Zhao, Min
Cui, Yan
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-03-03
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Acute kidney injury (AKI) is a critical care syndrome, which is usually associated with sepsis-related endotoxemia.
Evodiamine (EVO) is an active ingredient of many traditional medicinal formulations that possess a battery of biological activities.
In the study, we aimed to evaluate the potential protective effect of EVO against lipopolysaccharide- (LPS-) induced AKI and cytotoxicity.
LPS-resulted pathological injuries were significantly ameliorated by the administration of EVO.
EVO reduced the levels of blood urea nitrogen (BUN) and creatinine in LPS-treated rats.
EVO also inhibited LPS-induced reduction of cell viability in NRK-52E cells.
LPS-resulting increase of TNFα and IL-1β in both serum and kidney of rats and NRK-52E cells was inhibited by EVO.
LPS-induced increase of P65 NF-κB expression was markedly inhibited by EVO.
EVO-induced reduction of TNFα and IL-1β expression in LPS-treated cells was blocked by overexpression of P65 NF-κB.
Moreover, the increase of cell viability in LPS-treated cells induced by EVO was remarkably suppressed by overexpression of P65 NF-κB.
LPS-resulting increase of reactive oxygen species (ROS) production was suppressed by EVO.
H2O2 suppressed EVO-induced decrease of P65 NF-κB expression and increase of cell viability in LPS-treated NRK-52E cells.
Moreover, the antioxidant NAC significantly promoted EVO-induced decrease of P65 NF-κB expression and increase of cell viability in LPS-treated NRK-52E cells.
In conclusion, EVO had crucial protective effects against LPS-induced AKI and cytotoxicity through the antioxidant activities and thus the inhibition of inflammation.
Our data highlight EVO as a potential candidate for the development of new strategies for the treatment of AKI.
American Psychological Association (APA)
Shi, Yan& Hua, Qiuju& Li, Na& Zhao, Min& Cui, Yan. 2019. Protective Effects of Evodiamine against LPS-Induced Acute Kidney Injury through Regulation of ROS-NF-κB-Mediated Inflammation. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1148865
Modern Language Association (MLA)
Shi, Yan…[et al.]. Protective Effects of Evodiamine against LPS-Induced Acute Kidney Injury through Regulation of ROS-NF-κB-Mediated Inflammation. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1148865
American Medical Association (AMA)
Shi, Yan& Hua, Qiuju& Li, Na& Zhao, Min& Cui, Yan. Protective Effects of Evodiamine against LPS-Induced Acute Kidney Injury through Regulation of ROS-NF-κB-Mediated Inflammation. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1148865
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1148865