Sextuple Tumors in Head and Neck Area: Evidence of Field Cancerization
Joint Authors
Borges, Alvaro Henrique
Pereira, Thiago Machado
Ricci Volpato, Luiz Evaristo
Pivatto, Kellin
Nelem-Colturato, Carla Bento
Cury, Patrícia Maluf
Cosso, Isabelle Silva
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-08-15
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Background.
Field cancerization is a phenomenon in which prolonged exposure to carcinogens induces changes throughout the epithelium leaving the field ready for the appearance of premalignant or malignant lesions.
These alterations can promote the development of multiple carcinomas and explain the appearance of recurrences and second primary tumors.
The objective of this study was to report the case of a patient who developed six oral cavity tumors in five years of treatment and, also, demonstrate the immunohistochemical changes for p53 and Ki-67, routinely used to assess dysplasic regions.
Case Report.
When altered, p53 and Ki-67 suggest the presence of field cancers, an area with genetically altered cells, presenting a high risk of developing premalignant and malignant lesions.
This phenomenon explains the recurrence of malignant neoplasms after tumor resections.
Conclusion.
In addition, early identification of potentially malignant lesions in cases of second primary tumors is essential for effective treatment and patient survival, which usually have an unwelcoming prognosis.
American Psychological Association (APA)
Nelem-Colturato, Carla Bento& Cury, Patrícia Maluf& Pereira, Thiago Machado& Cosso, Isabelle Silva& Pivatto, Kellin& Ricci Volpato, Luiz Evaristo…[et al.]. 2018. Sextuple Tumors in Head and Neck Area: Evidence of Field Cancerization. Case Reports in Pathology،Vol. 2018, no. 2018, pp.1-4.
https://search.emarefa.net/detail/BIM-1148918
Modern Language Association (MLA)
Nelem-Colturato, Carla Bento…[et al.]. Sextuple Tumors in Head and Neck Area: Evidence of Field Cancerization. Case Reports in Pathology No. 2018 (2018), pp.1-4.
https://search.emarefa.net/detail/BIM-1148918
American Medical Association (AMA)
Nelem-Colturato, Carla Bento& Cury, Patrícia Maluf& Pereira, Thiago Machado& Cosso, Isabelle Silva& Pivatto, Kellin& Ricci Volpato, Luiz Evaristo…[et al.]. Sextuple Tumors in Head and Neck Area: Evidence of Field Cancerization. Case Reports in Pathology. 2018. Vol. 2018, no. 2018, pp.1-4.
https://search.emarefa.net/detail/BIM-1148918
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1148918