An Unusual Clinical Presentation of Solitary Fibrous Tumor in the Oral Cavity

Abstract EN

Solitary fibrous tumor is a rare neoplasm of mesenchymal origin that usually affects the pleura.

This rarity becomes more relevant in the oral cavity since the clinical features are nonspecific.

A 66-year-old female patient presented with a 3-month history of a swelling in the floor of the mouth, measuring 2 cm in greatest diameter, and pain symptomatology.

Occlusal and panoramic radiographs showed no bone involvement.

Ultrasonography of the submandibular and parotid salivary glands revealed normal morphology, dimensions, and echogenicity.

During this exam, a nodular image of low echogenicity measuring about 2.7 × 1.8 cm was detected.

An excisional biopsy was performed and histopathological analysis revealed a well-defined tumor-like lesion with alternation between hypercellular areas without a defined pattern and hypocellular areas.

On immunohistochemistry, the tumor was positive for CD34 and CD99 and negative for α-SMA, S-100, and bcl-2.

Combining the histopathological and immunohistochemical features, the diagnosis was solitary fibrous tumor.

The patient is under periodical clinical follow-up and shows no signs of recurrence 7 months after surgical excision of the tumor.

The combination of clinical-pathological and immunohistochemical features is necessary for the diagnosis.