Two Cases of Sinonasal Non-Intestinal-Type Adenocarcinoma with Squamoid Morules Expressing Nuclear β-Catenin and CDX2: A Curious Morphologic Finding Supported by Molecular Analysis
Joint Authors
Villatoro, Tatiana M.
Mardekian, Stacey K.
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-09-13
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Sinonasal non-intestinal-type adenocarcinoma (non-ITAC) is a rare, morphologically diverse neoplasm of the head and neck.
Squamoid morular metaplasia has recently been reported as an occasional finding in non-ITAC.
Interestingly, these squamoid morules often show aberrant expression of CDX2 as well as nuclear expression of β-catenin, similar to other tumors that show this type of metaplasia, but the underlying mechanism responsible for this finding is not completely understood.
We present two cases of low-grade non-ITAC with squamoid morules coexpressing CDX2 and nuclear β-catenin by immunohistochemistry, both of which were found to harbor a mutation in CTNNB1, the gene encoding β-catenin.
This finding provides support that an alteration in the β-catenin pathway, including mutations in the β-catenin gene itself, is responsible for this recently described morphologic phenomenon in non-ITAC.
American Psychological Association (APA)
Villatoro, Tatiana M.& Mardekian, Stacey K.. 2018. Two Cases of Sinonasal Non-Intestinal-Type Adenocarcinoma with Squamoid Morules Expressing Nuclear β-Catenin and CDX2: A Curious Morphologic Finding Supported by Molecular Analysis. Case Reports in Pathology،Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1148928
Modern Language Association (MLA)
Villatoro, Tatiana M.& Mardekian, Stacey K.. Two Cases of Sinonasal Non-Intestinal-Type Adenocarcinoma with Squamoid Morules Expressing Nuclear β-Catenin and CDX2: A Curious Morphologic Finding Supported by Molecular Analysis. Case Reports in Pathology No. 2018 (2018), pp.1-6.
https://search.emarefa.net/detail/BIM-1148928
American Medical Association (AMA)
Villatoro, Tatiana M.& Mardekian, Stacey K.. Two Cases of Sinonasal Non-Intestinal-Type Adenocarcinoma with Squamoid Morules Expressing Nuclear β-Catenin and CDX2: A Curious Morphologic Finding Supported by Molecular Analysis. Case Reports in Pathology. 2018. Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1148928
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1148928