Melanoma Mimicking Malignant Peripheral Nerve Sheath Tumor with Spread to the Cerebellopontine Angle: Utility of Next-Generation Sequencing in Diagnosis
Joint Authors
Walker, Ronald J.
Schwetye, Katherine E.
Fox Hanson, Katie
Birinyi, Paul
Raptis, Constantine
Chernock, Rebecca
Coppens, Jeroen
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-06-28
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Cutaneous spindle cell malignancy is associated with a broad differential diagnosis, particularly in the absence of a known primary melanocytic lesion.
We present an unusually challenging patient who presented with clinical symptoms involving cranial nerves VII and VIII and a parotid-region mass, which was S100-positive while lacking in melanocytic pigment and markers.
Over a year after resection of the parotid mass, both a cutaneous primary lentigo maligna melanoma and a metastatic CP angle melanoma were diagnosed in the same patient, prompting reconsideration of the diagnosis in the original parotid-region mass.
Next-generation sequencing of a panel of cancer-associated genes demonstrated 19 identical, clinically significant mutations as well as a high tumor mutation burden in both the parotid-region and CP angle tumors, indicating a metastatic relationship between the two and a melanocytic identity of the parotid-region tumor.
American Psychological Association (APA)
Fox Hanson, Katie& Birinyi, Paul& Walker, Ronald J.& Raptis, Constantine& Chernock, Rebecca& Coppens, Jeroen…[et al.]. 2018. Melanoma Mimicking Malignant Peripheral Nerve Sheath Tumor with Spread to the Cerebellopontine Angle: Utility of Next-Generation Sequencing in Diagnosis. Case Reports in Pathology،Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1148953
Modern Language Association (MLA)
Fox Hanson, Katie…[et al.]. Melanoma Mimicking Malignant Peripheral Nerve Sheath Tumor with Spread to the Cerebellopontine Angle: Utility of Next-Generation Sequencing in Diagnosis. Case Reports in Pathology No. 2018 (2018), pp.1-6.
https://search.emarefa.net/detail/BIM-1148953
American Medical Association (AMA)
Fox Hanson, Katie& Birinyi, Paul& Walker, Ronald J.& Raptis, Constantine& Chernock, Rebecca& Coppens, Jeroen…[et al.]. Melanoma Mimicking Malignant Peripheral Nerve Sheath Tumor with Spread to the Cerebellopontine Angle: Utility of Next-Generation Sequencing in Diagnosis. Case Reports in Pathology. 2018. Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1148953
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1148953