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PAX8 Distinguishes Diffuse Large B-Cell Lymphoma Mimicking Sarcoma
Joint Authors
Hirsch, Michelle S.
Nascimento, Alessandra F.
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-05-28
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
PAX8 is important for embryogenesis of the thyroid, Müllerian system, and upper urinary/renal tract, and expression of PAX8 has been described in carcinomas from each of these sites.
The sensitivity and specificity of the polyclonal PAX8 antibody in a large cohort of epithelial tumors as well as lymphomas have been previously determined, the latter because polyclonal PAX8 is known to be immunoreactive in nonneoplastic B-cell lymphocytes which are often used as the positive internal control for immunohistochemistry.
In this case report, PAX8 was a diagnostic clue for revising a previous diagnosis of unclassified high grade sarcoma to diffuse large B-cell lymphoma.
This case report demonstrates a pitfall for PAX8 immunoreactivity and acts as a reminder that lymphoma should be included in the differential diagnosis of a PAX8 positive, epithelial cell marker negative tumor of unknown primary origin.
American Psychological Association (APA)
Hirsch, Michelle S.& Nascimento, Alessandra F.. 2017. PAX8 Distinguishes Diffuse Large B-Cell Lymphoma Mimicking Sarcoma. Case Reports in Pathology،Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1148997
Modern Language Association (MLA)
Hirsch, Michelle S.& Nascimento, Alessandra F.. PAX8 Distinguishes Diffuse Large B-Cell Lymphoma Mimicking Sarcoma. Case Reports in Pathology No. 2017 (2017), pp.1-5.
https://search.emarefa.net/detail/BIM-1148997
American Medical Association (AMA)
Hirsch, Michelle S.& Nascimento, Alessandra F.. PAX8 Distinguishes Diffuse Large B-Cell Lymphoma Mimicking Sarcoma. Case Reports in Pathology. 2017. Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1148997
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1148997