The Successful Use of Infliximab in a Relapsing Case of Susac’s Syndrome
Joint Authors
Fernando, Suran L.
Boyle, Therese
Smith, Annika
Parratt, John D.E.
Source
Case Reports in Neurological Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-06-10
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Susac’s syndrome is a rare and debilitating disease characterized by the triad of encephalopathy, branch retinal artery occlusions, and sensorineural hearing loss.
All manifestations may not be clinically apparent at presentation resulting in delayed diagnosis.
Early recognition of the syndrome may prevent disease sequelae such as permanent cognitive, visual, and hearing loss.
We present such a case of Susac’s syndrome that was also refractory to conventionally prescribed combination of immunosuppressive treatments including high-dose potent corticosteroids, intravenous cyclophosphamide, methotrexate, plasma exchange, rituximab, and mycophenolate.
His disease was stabilized with infliximab in combination with a tapering course of low-dose prednisone.
After 2 years of remission with TNF treatment, consideration is being given to ceasing therapy.
He has the sequelae of bilateral sensorineural hearing loss but no visual impairment or cognitive deficits on follow-up with neuropsychometric testing.
This is the first case report to our knowledge of the successful use of infliximab for a patient with Susac’s syndrome that was necessary following treatment with cyclophosphamide and then rituximab.
American Psychological Association (APA)
Fernando, Suran L.& Boyle, Therese& Smith, Annika& Parratt, John D.E.. 2020. The Successful Use of Infliximab in a Relapsing Case of Susac’s Syndrome. Case Reports in Neurological Medicine،Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1149025
Modern Language Association (MLA)
Fernando, Suran L.…[et al.]. The Successful Use of Infliximab in a Relapsing Case of Susac’s Syndrome. Case Reports in Neurological Medicine No. 2020 (2020), pp.1-6.
https://search.emarefa.net/detail/BIM-1149025
American Medical Association (AMA)
Fernando, Suran L.& Boyle, Therese& Smith, Annika& Parratt, John D.E.. The Successful Use of Infliximab in a Relapsing Case of Susac’s Syndrome. Case Reports in Neurological Medicine. 2020. Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1149025
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1149025