Transient, Recurrent Central Nervous System Clinical Manifestations of X-Linked Charcot-Marie-Tooth Disease Presenting with Very Long Latency Periods between Episodes: Is Prolonged Sun Exposure a Provoking Factor?
Joint Authors
Kleopa, Kleopas A.
Tziakouri, Andria
Natsiopoulos, Konstantinos
Michaelides, Costas
Source
Case Reports in Neurological Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-06-27
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Charcot-Marie-Tooth disease is one of the most common inherited neurological disorders affecting the peripheral nervous system.
The common clinical manifestations of the disease are distal muscle weakness and atrophy, often associated with a characteristic steppage gait and foot deformities.
Transient acute and recurrent or chronic central nervous system manifestations, predominantly, dysarthria, dysphagia, motor weakness, and ataxia, have been recognized as a feature of the X-linked type 1 of CMT (CMTX1).
The CNS symptoms occur typically in young age and often precede the clinical manifestation of the polyneuropathy.
Several predisposing factors such as exercise, fever, and returning from areas of high altitude have been described as triggers of the CNS symptoms; however, in many cases, a substantial cause remains undetermined.
In this report, we describe a patient with three attacks of transient CNS deficits at the ages of 11, 21, and 38 years, respectively, which were also accompanied by transient white matter abnormalities on MRI.
Two of the attacks occurred after prolonged exposure to sunlight.
In our knowledge, this is the first documented case with such long latency periods between CNS attacks as well as the only report describing intense sun exposure as a possible provoking factor.
American Psychological Association (APA)
Tziakouri, Andria& Natsiopoulos, Konstantinos& Kleopa, Kleopas A.& Michaelides, Costas. 2020. Transient, Recurrent Central Nervous System Clinical Manifestations of X-Linked Charcot-Marie-Tooth Disease Presenting with Very Long Latency Periods between Episodes: Is Prolonged Sun Exposure a Provoking Factor?. Case Reports in Neurological Medicine،Vol. 2020, no. 2020, pp.1-5.
https://search.emarefa.net/detail/BIM-1149033
Modern Language Association (MLA)
Tziakouri, Andria…[et al.]. Transient, Recurrent Central Nervous System Clinical Manifestations of X-Linked Charcot-Marie-Tooth Disease Presenting with Very Long Latency Periods between Episodes: Is Prolonged Sun Exposure a Provoking Factor?. Case Reports in Neurological Medicine No. 2020 (2020), pp.1-5.
https://search.emarefa.net/detail/BIM-1149033
American Medical Association (AMA)
Tziakouri, Andria& Natsiopoulos, Konstantinos& Kleopa, Kleopas A.& Michaelides, Costas. Transient, Recurrent Central Nervous System Clinical Manifestations of X-Linked Charcot-Marie-Tooth Disease Presenting with Very Long Latency Periods between Episodes: Is Prolonged Sun Exposure a Provoking Factor?. Case Reports in Neurological Medicine. 2020. Vol. 2020, no. 2020, pp.1-5.
https://search.emarefa.net/detail/BIM-1149033
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1149033