Primary Hepatic Neuroendocrine Tumor with Unusual Thyroid Follicular-Like Morphologic Characteristics
Joint Authors
Zhai, Qihui “Jim”
Ibrahim, Mohd Elmugtaba
Abadeer, Kerolos
Nassar, Aziza
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-02-20
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
We describe a primary hepatic neuroendocrine tumor of a 57-year-old Thai woman who presented in 2004 with a suspicious mass in the left hepatic lobe.
She underwent left hepatectomy for the 10.5-cm mass, called intermediate grade neuroendocrine carcinoma of unknown origin, likely metastatic.
The tumor recurred in 2007, then called recurrent primary hepatic neuroendocrine tumor (PHNET), and the patient underwent liver transplant.
Because of similarity between the neuroendocrine tumor and a thyroid tumor—specifically, follicular-like characteristics—immunohistochemical stains for thyroglobulin, TTF1, and calcitonin were performed.
However, all were negative.
All imaging studies revealed no evidence of a primary lesion other than the liver mass.
In 2008, the patient’s liver transplant failed because of ischemic cholangiopathy, and she underwent a second liver transplant.
Seven years later, in 2015, she presented with metastatic neuroendocrine tumor of intermediate grade to the lung, consistent with metastatic PHNET.
She underwent left upper-lobe wedge resection to remove the tumor.
The patient is alive with no evidence of disease at 13 years after initial diagnosis.
This rare variant of PHNET had thyroid-like morphologic characteristics but there is no evidence of primary thyroid tumor or thyroid markers in the primary and recurrent hepatic tumors and lung metastasis.
American Psychological Association (APA)
Ibrahim, Mohd Elmugtaba& Abadeer, Kerolos& Zhai, Qihui “Jim”& Nassar, Aziza. 2017. Primary Hepatic Neuroendocrine Tumor with Unusual Thyroid Follicular-Like Morphologic Characteristics. Case Reports in Pathology،Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1149052
Modern Language Association (MLA)
Ibrahim, Mohd Elmugtaba…[et al.]. Primary Hepatic Neuroendocrine Tumor with Unusual Thyroid Follicular-Like Morphologic Characteristics. Case Reports in Pathology No. 2017 (2017), pp.1-6.
https://search.emarefa.net/detail/BIM-1149052
American Medical Association (AMA)
Ibrahim, Mohd Elmugtaba& Abadeer, Kerolos& Zhai, Qihui “Jim”& Nassar, Aziza. Primary Hepatic Neuroendocrine Tumor with Unusual Thyroid Follicular-Like Morphologic Characteristics. Case Reports in Pathology. 2017. Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1149052
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1149052