Acupuncture for Primary Osteoporosis: Evidence, Potential Treatment Prescriptions, and Mechanisms
Joint Authors
Xu, Nenggui
Lin, Haixiong
Wang, Xiaotong
Mo, Yingjie
Lin, Chunni
Huang, Feng
Chen, Yongjun
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-06-12
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Many clinical trials and meta-analyses related to acupuncture for osteoporosis (OP) have been published.
However, identifying the evidence from these studies still remains a challenge for acupuncturists.
We conducted a systematic search of the Chinese Biomedical Medicine (CBM), VIP Database, Wanfang Data, China National Knowledge Infrastructure (CNKI), PubMed, Springer, Cochrane Library, and Embase to identify relevant trials, systematic reviews, and/or meta-analyses up to October 31, 2018.
Data were extracted to assess the methodological quality using Veritas plots and to explore potential acupuncture prescriptions using the Traditional Chinese Medicine inheritance support system (TCMISS).
In addition, potential mechanisms of core acupoints identified by data mining were summarized based on published studies.
A total of 218 clinical trials and ten meta-analyses were included, involving 212 acupuncture prescriptions, 102 acupoints, 13 meridians, three extra meridians, and one Ashi point.
The mean Veritas score of publication year, type of study, Assessment of Multiple Systematic Reviews 2, Preferred Reporting Items for Systematic Reviews and Meta-Analyses, heterogeneity, and publication bias were 5.5, 7.2, 6, 5.6, 5.8, and 7.5, respectively.
The study of Pan et al.
received the highest Veritas score of 8.67 points.
The most frequently used meridian was BL.
Acupoint combinations BL23 and BL20, BL23 and GV4, and BL23 and ST36 were used frequently.
The core acupoints association networks were acupoints BL23, BL20, ST36, GV4, SP6, CV4, and KI3.
The potential mechanisms of core acupoints involved upregulated expression of members in OPG/RANKL, Wnt/β-catenin, and MAPK pathways, such as LRP5, β-catenin, Runx2, and OPG.
In conclusion, our Veritas plots enable acupuncturists to evaluate key attributes of meta-analysis quality related to acupuncture for primary OP and to improve the quality of evidence-based medicine relating to acupuncture.
Data mining analysis revealed an association network of meridians, acupoint combinations, core acupoints, and the underlying mechanisms of acupuncture for primary OP.
American Psychological Association (APA)
Lin, Haixiong& Wang, Xiaotong& Mo, Yingjie& Lin, Chunni& Xu, Nenggui& Huang, Feng…[et al.]. 2019. Acupuncture for Primary Osteoporosis: Evidence, Potential Treatment Prescriptions, and Mechanisms. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-15.
https://search.emarefa.net/detail/BIM-1149068
Modern Language Association (MLA)
Lin, Haixiong…[et al.]. Acupuncture for Primary Osteoporosis: Evidence, Potential Treatment Prescriptions, and Mechanisms. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-15.
https://search.emarefa.net/detail/BIM-1149068
American Medical Association (AMA)
Lin, Haixiong& Wang, Xiaotong& Mo, Yingjie& Lin, Chunni& Xu, Nenggui& Huang, Feng…[et al.]. Acupuncture for Primary Osteoporosis: Evidence, Potential Treatment Prescriptions, and Mechanisms. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-15.
https://search.emarefa.net/detail/BIM-1149068
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1149068