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Keratoacanthoma of the Nasal Septum Secondary to Ranibizumab Use
Joint Authors
Cohn, Jason E.
Spector, Harvey
Caruso Sales, Hilary M.
Nguyen, Giang Huong
Briskin, Kenneth
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-05-11
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Keratoacanthoma (KA) is a benign epithelial tumor that typically presents as a firm, cone-shaped, flesh-colored nodule with a central horn-filled crater.
KA is considered to be a low-grade variant of squamous cell carcinoma (SCC).
We report a rare case of a 72-year-old male who presented with a KA involving the nasal septum, possibly related to ranibizumab use.
A flesh-colored lesion on the right anterior nasal septum lesion was visualized on examination.
Histologic examination revealed a well-circumscribed, dome-shaped central crater filled with keratin, well-differentiated squamous epithelium with ground-glass cytoplasm with pushing margins, and intraepithelial microabscesses establishing the diagnosis of KA.
KA of the nasal septum has only been reported once in the literature.
This case is unusual because it normally presents on sun-exposed areas.
Additionally, this patient was taking ranibizumab, a vascular endothelial growth factor (VEGF) inhibitor for macular degeneration.
Despite ranibizumab not being directly linked to precancerous and cancerous skin lesions, agents in this medication class have been.
Although it is difficult to prove associations in this isolated case, the role of ranibizumab causing cutaneous lesions should be further investigated.
American Psychological Association (APA)
Cohn, Jason E.& Caruso Sales, Hilary M.& Nguyen, Giang Huong& Spector, Harvey& Briskin, Kenneth. 2017. Keratoacanthoma of the Nasal Septum Secondary to Ranibizumab Use. Case Reports in Pathology،Vol. 2017, no. 2017, pp.1-4.
https://search.emarefa.net/detail/BIM-1149072
Modern Language Association (MLA)
Cohn, Jason E.…[et al.]. Keratoacanthoma of the Nasal Septum Secondary to Ranibizumab Use. Case Reports in Pathology No. 2017 (2017), pp.1-4.
https://search.emarefa.net/detail/BIM-1149072
American Medical Association (AMA)
Cohn, Jason E.& Caruso Sales, Hilary M.& Nguyen, Giang Huong& Spector, Harvey& Briskin, Kenneth. Keratoacanthoma of the Nasal Septum Secondary to Ranibizumab Use. Case Reports in Pathology. 2017. Vol. 2017, no. 2017, pp.1-4.
https://search.emarefa.net/detail/BIM-1149072
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1149072