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Pediatric Pulmonary Epstein-Barr Virus-Positive Diffuse Large B-Cell Lymphoma: A Case Report and Review of the Literature
Joint Authors
Shackelford, Rodney E.
Wei, Eric X.
Cotelingam, James D.
Silva, Roberto F.
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-10-08
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Non-Hodgkin’s lymphoma (NHL) is a common malignancy of childhood; however, a lung primary presentation is an uncommon finding, as is finding an association with the Epstein-Barr virus (EBV).
We report the case of a 23-month-old female who developed EBV-associated diffuse large B-cell lymphoma (DLBCL) that was initially thought to be pneumonia.
Extensive tissue necrosis, focal angioinvasion, and angiodestruction were observed.
She was refractory to various therapy regimens, subsequently developed DLBCL in the central nervous system, and eventually expired.
Although EBV+ DLBCL was initially considered to occur predominantly in elderly patients over 50 years of age, it is now increasingly recognized to occur in younger patients with primarily nodal involvement who have overall better prognoses.
To our knowledge, this case is the first reported EBV+ DLBCL occurring in a patient below two years of age with lung involvement as the initial clinical presentation.
American Psychological Association (APA)
Wei, Eric X.& Silva, Roberto F.& Cotelingam, James D.& Shackelford, Rodney E.. 2017. Pediatric Pulmonary Epstein-Barr Virus-Positive Diffuse Large B-Cell Lymphoma: A Case Report and Review of the Literature. Case Reports in Pathology،Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1149093
Modern Language Association (MLA)
Wei, Eric X.…[et al.]. Pediatric Pulmonary Epstein-Barr Virus-Positive Diffuse Large B-Cell Lymphoma: A Case Report and Review of the Literature. Case Reports in Pathology No. 2017 (2017), pp.1-5.
https://search.emarefa.net/detail/BIM-1149093
American Medical Association (AMA)
Wei, Eric X.& Silva, Roberto F.& Cotelingam, James D.& Shackelford, Rodney E.. Pediatric Pulmonary Epstein-Barr Virus-Positive Diffuse Large B-Cell Lymphoma: A Case Report and Review of the Literature. Case Reports in Pathology. 2017. Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1149093
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1149093