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Primary Clear Cell Microcystic Adenoma of the Sinonasal Cavity: Pathological or Fortuitous Association?
Joint Authors
Cooper, Rosalin
Markham, Hannah
Theaker, Jeffery
Bateman, Adrian
Sommerlad, Matthew
Crawford, Gillian
Eccles, Diana
Bunyan, D. J.
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-02-05
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Primary clear cell microcystic adenoma of the sinonasal cavity is rare.
It has previously been described only as a VHL-associated tumour.
Von Hippel-Lindau (VHL) syndrome is an inherited cancer syndrome characterised by an elevated risk of neoplasia including clear cell renal cell carcinoma (ccRCC), haemangioblastoma, and phaeochromocytoma.
We describe the second reported case of a primary clear cell microcystic adenoma of the sinonasal cavity.
The 39-year-old patient with VHL syndrome had previously undergone resection and ablation of ccRCC.
He presented with epistaxis.
Imaging demonstrated a mass in the ethmoid sinus.
Initial clinical suspicion was of metastatic ccRCC.
However, tumour morphology and immunoprofile were distinct from the previous ccRCC and supported a diagnosis of primary microcystic adenoma.
Analysis of DNA extracted from sinonasal tumour tissue did not show loss of the wild-type allele at the VHL locus.
Although this did not support tumour association with VHL disease, it was not possible to look for a loss-of-function mutation.
The association of primary microcystic adenoma of the sinonasal cavity with VHL disease remains speculative.
These lesions are benign but are likely to require regular surveillance.
Such tumours may require repeated surgical excision.
American Psychological Association (APA)
Cooper, Rosalin& Markham, Hannah& Theaker, Jeffery& Bateman, Adrian& Bunyan, D. J.& Sommerlad, Matthew…[et al.]. 2017. Primary Clear Cell Microcystic Adenoma of the Sinonasal Cavity: Pathological or Fortuitous Association?. Case Reports in Pathology،Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1149107
Modern Language Association (MLA)
Cooper, Rosalin…[et al.]. Primary Clear Cell Microcystic Adenoma of the Sinonasal Cavity: Pathological or Fortuitous Association?. Case Reports in Pathology No. 2017 (2017), pp.1-5.
https://search.emarefa.net/detail/BIM-1149107
American Medical Association (AMA)
Cooper, Rosalin& Markham, Hannah& Theaker, Jeffery& Bateman, Adrian& Bunyan, D. J.& Sommerlad, Matthew…[et al.]. Primary Clear Cell Microcystic Adenoma of the Sinonasal Cavity: Pathological or Fortuitous Association?. Case Reports in Pathology. 2017. Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1149107
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1149107