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Moxibustion Exerts a Neuroprotective Effect through Antiferroptosis in Parkinson’s Disease
Joint Authors
Zhang, Guiyu
Lu, Juan
Liu, Xuelei
Tian, Ye
Li, Hang
Ren, Zhenxing
Liang, Shuang
Zhao, Caiping
Li, Xinrong
Wang, Tingting
Chen, Dongfeng
Kuang, Weihong
Zhu, Meiling
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-07-31
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The objective of this study was to explore the neuroprotective effect of moxibustion on rats with Parkinson’s disease (PD) and its mechanism.
A Parkinson’s disease model was established in rats using a two-point stereotactic 6-hydroxydopamine injection in the right substantia nigra (SN) and ventral tegmental area.
The rats received moxibustion at the Baihui (GV20) and Sishencong (EX-HN1) acupoints for 20 minutes, six times a week, for 6 weeks.
The right SN tissue was histologically and immunohistochemically examined.
Differentially expressed genes (DEGs) were identified through RNA sequencing.
In addition, the levels of tyrosine hydroxylase (TH), glutathione peroxidase 4 (GPX4), and ferritin heavy chain 1 (FTH1) in SN were measured.
In comparison to the model group, the moxibustion group showed a significantly greater TH immunoreactivity and a higher behavioural score.
In particular, moxibustion led to an increase in the number and morphological stability of SN neural cells.
The functional pathway analysis showed that DEGs are closely related to the ferroptosis pathway.
GPX4 and FTH1 in the SN were significantly overexpressed in the moxibustion-treated rats with PD.
Moxibustion can effectively reduce the death of SN neurons, decrease the occurrence of ferroptosis, and increase the TH activity to protect the neurons in rats with PD.
The protective mechanism may be associated with suppression of the ferroptosis.
American Psychological Association (APA)
Lu, Juan& Liu, Xuelei& Tian, Ye& Li, Hang& Ren, Zhenxing& Liang, Shuang…[et al.]. 2019. Moxibustion Exerts a Neuroprotective Effect through Antiferroptosis in Parkinson’s Disease. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1149111
Modern Language Association (MLA)
Lu, Juan…[et al.]. Moxibustion Exerts a Neuroprotective Effect through Antiferroptosis in Parkinson’s Disease. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1149111
American Medical Association (AMA)
Lu, Juan& Liu, Xuelei& Tian, Ye& Li, Hang& Ren, Zhenxing& Liang, Shuang…[et al.]. Moxibustion Exerts a Neuroprotective Effect through Antiferroptosis in Parkinson’s Disease. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1149111
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1149111