Grade 4 Pneumonitis in a Patient Treated with a Combination of Gemcitabine and Docetaxel for Recurrent Leiomyosarcoma of the Uterus
Joint Authors
Mankowski Gettle, Lori
Rose, Stephen
Spencer, Ryan J.
Wang, Connor
Source
Case Reports in Obstetrics and Gynecology
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-02-07
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Gemcitabine and docetaxel combination chemotherapy is the standard of care for patients with unresectable recurrent or metastatic leiomyosarcoma of the uterus.
Although they are generally well-tolerated agents, they can also cause severe and life-threatening pulmonary toxicities.
Here, we describe a case of grade 4 pneumonitis due to gemcitabine and docetaxel in a 74-year-old woman with recurrent, metastatic uterine leiomyosarcoma.
Despite early recognition of chemotherapy-induced lung injury and early administration of corticosteroid, she developed noncardiogenic pulmonary edema, diffuse alveolar hemorrhage, and acute respiratory distress syndrome.
She required multiple intubations and a tracheostomy.
Physicians should not only be aware of gemcitabine and docetaxel’s potential to cause life-threatening pulmonary injuries but also recognize the variability in clinical presentations and treatment responses, the radiographic findings of these lung toxicities, and the need for early corticosteroid therapy in these cases.
American Psychological Association (APA)
Wang, Connor& Rose, Stephen& Mankowski Gettle, Lori& Spencer, Ryan J.. 2020. Grade 4 Pneumonitis in a Patient Treated with a Combination of Gemcitabine and Docetaxel for Recurrent Leiomyosarcoma of the Uterus. Case Reports in Obstetrics and Gynecology،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1149112
Modern Language Association (MLA)
Wang, Connor…[et al.]. Grade 4 Pneumonitis in a Patient Treated with a Combination of Gemcitabine and Docetaxel for Recurrent Leiomyosarcoma of the Uterus. Case Reports in Obstetrics and Gynecology No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1149112
American Medical Association (AMA)
Wang, Connor& Rose, Stephen& Mankowski Gettle, Lori& Spencer, Ryan J.. Grade 4 Pneumonitis in a Patient Treated with a Combination of Gemcitabine and Docetaxel for Recurrent Leiomyosarcoma of the Uterus. Case Reports in Obstetrics and Gynecology. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1149112
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1149112