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Novel Acaricidal Drug Fluazuron Causes Immunotoxicity via Selective Depletion of Lymphocytes T CD8
Joint Authors
Ribeiro, Juliana Gonçalves
Soares, Anelise Santos
Chaves, Pamella Eduardha Espindola
Limberger, Jéssica Tamara
da Rosa, Emanoeli
Zuravski, Luísa
Oliveira, Luís Flávio Souza de
Machado, Michel Mansur
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-05-07
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Fluazuron is one of the newest veterinary antitick medicines.
Belonging to the benzoylphenylureas group, its mechanism of action acts by the interference of the formation of the chitin of the tick, which is responsible for the hardening of its exoskeletons.
In addition to taking care of the health of the animal so that it receives the medication in the doses and the correct form, it is important to analyze the safety of the operator.
Reduced resistance to infectious disease was a well-documented consequence of primary and acquired immunodeficiencies, but a novel finding following xenobiotic exposure.
The awareness of the consequences of altered immune function is the most likely outcome of inadvertent exposure.
The human health implications of studies in which chemical exposure reduced resistance to infection drove an early focus on immunosuppression within the toxicology community.
The main objective is to perform the evaluation by computational platforms and in cell culture, searching for data that can serve as a foundation for a better understanding of the toxic effects involved with the accidental contamination of Fluazuron and, thus, to assist the medical community and users to understand the risks inherent in its use.
As far as we can determine in the literature, our work has unmistakably demonstrated that the Fluazuron can cause genotoxicity by probable chromatin rearrangement and immunodepleting by specific reduction of the CD8 T lymphocyte subpopulation, mediated by the decrease in gamma interferon production.
Although the use of Fluazuron is a necessity for tick control and for cattle management, we must bear in mind that the imminent risks to its application exist.
Careless use can damage the immune system which in turn carries a gigantic hazard by opening a door to diseases and pathogens and leaving us defenseless.
American Psychological Association (APA)
Ribeiro, Juliana Gonçalves& Soares, Anelise Santos& Chaves, Pamella Eduardha Espindola& Limberger, Jéssica Tamara& da Rosa, Emanoeli& Zuravski, Luísa…[et al.]. 2019. Novel Acaricidal Drug Fluazuron Causes Immunotoxicity via Selective Depletion of Lymphocytes T CD8. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1149132
Modern Language Association (MLA)
Ribeiro, Juliana Gonçalves…[et al.]. Novel Acaricidal Drug Fluazuron Causes Immunotoxicity via Selective Depletion of Lymphocytes T CD8. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-7.
https://search.emarefa.net/detail/BIM-1149132
American Medical Association (AMA)
Ribeiro, Juliana Gonçalves& Soares, Anelise Santos& Chaves, Pamella Eduardha Espindola& Limberger, Jéssica Tamara& da Rosa, Emanoeli& Zuravski, Luísa…[et al.]. Novel Acaricidal Drug Fluazuron Causes Immunotoxicity via Selective Depletion of Lymphocytes T CD8. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1149132
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1149132