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Langerhans Cell Sarcoma: A Case Report Demonstrating Morphological and Immunophenotypical Variability within a Single Lesion
Joint Authors
Singh, Rasika
Keen, Charles Edward
Stone, Christopher
Sarsfield, Patrick
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-05-24
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Langerhans cells are antigen presenting dendritic cells and tumours arising from these are rare.
The tumours arising from these dendritic cells are divided into two categories according to a WHO classification: Langerhans cell histiocytosis and Langerhans cell sarcoma.
It is the degree of atypia and clinical aggressiveness that distinguishes the two subtypes.
Langerhans cell sarcoma (LCS) is a neoplastic proliferation of Langerhans cells which can occur in skin, bone marrow, lymph nodes, spleen, liver, and lung.
LCS can present with multiple cutaneous and systemic lesions.
We present a case of Langerhans cell sarcoma with a unique morphological appearance and variable immunohistochemical profile within a single cutaneous lesion.
LCS is a rare malignancy and its diagnosis is based on morphology, immunophenotypical examination, and ultrastructural analysis by electron microscopy.
Our case highlights a unique morphological description of LCS wherein the pleomorphic neoplastic cells show epidermotropism and are surrounded by a variable amount of inflammatory infiltrate within a single cutaneous lesion.
A single cutaneous lesion of Langerhans cell sarcoma with variable immunohistochemical profile has not been described so far.
American Psychological Association (APA)
Singh, Rasika& Keen, Charles Edward& Stone, Christopher& Sarsfield, Patrick. 2017. Langerhans Cell Sarcoma: A Case Report Demonstrating Morphological and Immunophenotypical Variability within a Single Lesion. Case Reports in Pathology،Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1149135
Modern Language Association (MLA)
Singh, Rasika…[et al.]. Langerhans Cell Sarcoma: A Case Report Demonstrating Morphological and Immunophenotypical Variability within a Single Lesion. Case Reports in Pathology No. 2017 (2017), pp.1-5.
https://search.emarefa.net/detail/BIM-1149135
American Medical Association (AMA)
Singh, Rasika& Keen, Charles Edward& Stone, Christopher& Sarsfield, Patrick. Langerhans Cell Sarcoma: A Case Report Demonstrating Morphological and Immunophenotypical Variability within a Single Lesion. Case Reports in Pathology. 2017. Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1149135
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1149135