Antihypertensive Activity of Leersia hexandra Sw. (Poaceae) Aqueous Extract on Ethanol-Induced Hypertension in Wistar Rat
Joint Authors
Kamtchouing, Pierre
Dimo, Théophile
Bilanda, Danielle Claude
Tcheutchoua, Yannick Carlos
Djomeni Dzeufiet, Paul Désiré
Fokou, Daniel Lauré Dongmo
Fouda, Yannick Bekono
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-01-06
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Leersia hexandra (L.
hexandra) is used in traditional medicine to treat many diseases including hypertension.
This study aimed to evaluate the curative effects of the aqueous extract of L.
hexandra on hypertension.
Hypertension was induced in rats by oral administration of ethanol (5 g/kg/day) for five weeks.
The animals were divided into 2 groups: one group of 5 rats receiving distilled water (10 mL/kg) and another group of 20 rats receiving ethanol.
At the end of the 5 weeks of administration of ethanol, the animals were divided into 4 groups of 5 rats each: one group of hypertensive rats receiving distilled water (10 mL/kg), another one receiving nifedipine (10 mg/kg), and two groups of hypertensive rats receiving L.
hexandra at doses of 100 and 200 mg/kg, respectively.
The results showed that ethanol induced a significant increase in the mean arterial pressure (MAP) and heart rate of normotensive rats.
The administration of the extract (100 and 200 mg/kg) or nifedipine caused a significant decrease of MAP compared to hypertensive rats.
Ethanol induced a significant increase of lipid profile, the atherogenic index, creatinine, and transaminase activities.
Ethanol also induced a significant decrease in serum HDL-cholesterol and antioxidant markers evaluated.
Treatment of hypertensive rats with L.
hexandra or nifedipine significantly improved lipid profile, hepatic and renal functions, and antioxidant status.
The curative effect of L.
hexandra extract on hypertension is probably related to its antihypertensive, hypolipidemic, and antioxidant activities, which justifies its empirical use in the treatment of hypertension.
American Psychological Association (APA)
Bilanda, Danielle Claude& Tcheutchoua, Yannick Carlos& Djomeni Dzeufiet, Paul Désiré& Fokou, Daniel Lauré Dongmo& Fouda, Yannick Bekono& Dimo, Théophile…[et al.]. 2019. Antihypertensive Activity of Leersia hexandra Sw. (Poaceae) Aqueous Extract on Ethanol-Induced Hypertension in Wistar Rat. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1149155
Modern Language Association (MLA)
Bilanda, Danielle Claude…[et al.]. Antihypertensive Activity of Leersia hexandra Sw. (Poaceae) Aqueous Extract on Ethanol-Induced Hypertension in Wistar Rat. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1149155
American Medical Association (AMA)
Bilanda, Danielle Claude& Tcheutchoua, Yannick Carlos& Djomeni Dzeufiet, Paul Désiré& Fokou, Daniel Lauré Dongmo& Fouda, Yannick Bekono& Dimo, Théophile…[et al.]. Antihypertensive Activity of Leersia hexandra Sw. (Poaceae) Aqueous Extract on Ethanol-Induced Hypertension in Wistar Rat. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1149155
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1149155