Signal Transduction Pathways of Acupuncture for Treating Some Nervous System Diseases
Joint Authors
Lai, Hsiang-Chun
Chang, Qwang-Yuen
Hsieh, Ching-Liang
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-37, 37 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-07-11
Country of Publication
Egypt
No. of Pages
37
Main Subjects
Abstract EN
In this article, we review signal transduction pathways through which acupuncture treats nervous system diseases.
We electronically searched the databases, including PubMed, MEDLINE, clinical Key, the Cochrane Library, and the China National Knowledge Infrastructure from their inception to December 2018 using the following MeSH headings and keywords alone or in varied combination: acupuncture, molecular, signal transduction, genetic, cerebral ischemic injury, cerebral hemorrhagic injury, stroke, epilepsy, seizure, depression, Alzheimer’s disease, dementia, vascular dementia, and Parkinson’s disease.
Acupuncture treats nervous system diseases by increasing the brain-derived neurotrophic factor level and involves multiple signal pathways, including p38 MAPKs, Raf/MAPK/ERK 1/2, TLR4/ERK, PI3K/AKT, AC/cAMP/PKA, ASK1-JNK/p38, and downstream CREB, JNK, m-TOR, NF-κB, and Bcl-2/Bax balance.
Acupuncture affects synaptic plasticity, causes an increase in neurotrophic factors, and results in neuroprotection, cell proliferation, antiapoptosis, antioxidant activity, anti-inflammation, and maintenance of the blood-brain barrier.
American Psychological Association (APA)
Lai, Hsiang-Chun& Chang, Qwang-Yuen& Hsieh, Ching-Liang. 2019. Signal Transduction Pathways of Acupuncture for Treating Some Nervous System Diseases. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-37.
https://search.emarefa.net/detail/BIM-1149158
Modern Language Association (MLA)
Lai, Hsiang-Chun…[et al.]. Signal Transduction Pathways of Acupuncture for Treating Some Nervous System Diseases. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-37.
https://search.emarefa.net/detail/BIM-1149158
American Medical Association (AMA)
Lai, Hsiang-Chun& Chang, Qwang-Yuen& Hsieh, Ching-Liang. Signal Transduction Pathways of Acupuncture for Treating Some Nervous System Diseases. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-37.
https://search.emarefa.net/detail/BIM-1149158
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1149158