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Management of Refractory Menstrual Bleeding in an Adolescent with Glanzmann Thrombasthenia: A Case Report and Review
Joint Authors
King, Luke J.
Huff, Jessie
Heber, Deidre
Miller, Michal Ann
Marshall, Brytanie
Source
Case Reports in Obstetrics and Gynecology
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-3, 3 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-09-30
Country of Publication
Egypt
No. of Pages
3
Main Subjects
Abstract EN
Glanzmann Thrombasthenia is a rare bleeding disorder causing life-threatening bleeding at menarche in the adolescent female.
Bleeding often necessitates admission and multiple blood transfusions.
Due to the rarity of the disease, management of acute bleeding in new-onset menarche poses a particular challenge.
A 12-year-old menarchial female had persistent vaginal bleeding despite multiple treatment modalities including aminocaproic acid, recombinant factor VIIa, intravenous estrogen, and gonadotropin receptor hormone agonists.
Although the standard treatment of bleeding in patients with GT is primarily rFVIIa, new-onset menstrual bleeding in conjunction with an immature hypothalamic-pituitary-ovarian axis often requires expanding treatment to include multiple drug modalities.
In our case, a two-step approach was necessary.
The first is targeting the cessation of the first menses.
The second is optimizing ongoing management of long-term control of heavy menstrual bleeding to achieve amenorrhea, prevent further hospital admissions, and avoid recurrent transfusions.
American Psychological Association (APA)
King, Luke J.& Huff, Jessie& Heber, Deidre& Miller, Michal Ann& Marshall, Brytanie. 2020. Management of Refractory Menstrual Bleeding in an Adolescent with Glanzmann Thrombasthenia: A Case Report and Review. Case Reports in Obstetrics and Gynecology،Vol. 2020, no. 2020, pp.1-3.
https://search.emarefa.net/detail/BIM-1149217
Modern Language Association (MLA)
King, Luke J.…[et al.]. Management of Refractory Menstrual Bleeding in an Adolescent with Glanzmann Thrombasthenia: A Case Report and Review. Case Reports in Obstetrics and Gynecology No. 2020 (2020), pp.1-3.
https://search.emarefa.net/detail/BIM-1149217
American Medical Association (AMA)
King, Luke J.& Huff, Jessie& Heber, Deidre& Miller, Michal Ann& Marshall, Brytanie. Management of Refractory Menstrual Bleeding in an Adolescent with Glanzmann Thrombasthenia: A Case Report and Review. Case Reports in Obstetrics and Gynecology. 2020. Vol. 2020, no. 2020, pp.1-3.
https://search.emarefa.net/detail/BIM-1149217
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1149217