P53 and PIK3CA Mutations in KRASHER2 Negative Ovarian Intestinal-Type Mucinous Carcinoma Associated with Mature Teratoma
Joint Authors
Buri, Sarah
D’Haene, Nicky
Noël, Jean-Christophe
Catteau, Xavier
Simon, Philippe
Source
Case Reports in Obstetrics and Gynecology
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-07-22
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Primary ovarian intestinal-type mucinous carcinomas associated with mature teratoma are rare and represent less than 3% of all primary ovarian neoplasms.
The molecular profile of these tumors is still controversial.
We report here the first case of mucinous ovarian tumor in which mutation of the PIK3CA and P53 genes could be demonstrated by the next generation sequencing technique without KRAS mutation or HER2 amplification.
Our data suggest that these mucinous carcinoma variants probably present an extremely complex molecular biology profile that should be known in the future to stratify therapeutic outcomes and potential targeted therapies, particularly in recurrent disease.
American Psychological Association (APA)
Buri, Sarah& Simon, Philippe& D’Haene, Nicky& Catteau, Xavier& Noël, Jean-Christophe. 2020. P53 and PIK3CA Mutations in KRASHER2 Negative Ovarian Intestinal-Type Mucinous Carcinoma Associated with Mature Teratoma. Case Reports in Obstetrics and Gynecology،Vol. 2020, no. 2020, pp.1-4.
https://search.emarefa.net/detail/BIM-1149238
Modern Language Association (MLA)
Buri, Sarah…[et al.]. P53 and PIK3CA Mutations in KRASHER2 Negative Ovarian Intestinal-Type Mucinous Carcinoma Associated with Mature Teratoma. Case Reports in Obstetrics and Gynecology No. 2020 (2020), pp.1-4.
https://search.emarefa.net/detail/BIM-1149238
American Medical Association (AMA)
Buri, Sarah& Simon, Philippe& D’Haene, Nicky& Catteau, Xavier& Noël, Jean-Christophe. P53 and PIK3CA Mutations in KRASHER2 Negative Ovarian Intestinal-Type Mucinous Carcinoma Associated with Mature Teratoma. Case Reports in Obstetrics and Gynecology. 2020. Vol. 2020, no. 2020, pp.1-4.
https://search.emarefa.net/detail/BIM-1149238
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1149238