Propylene Glycol Toxicity in Adolescent with Refractory Myoclonic Status Epilepticus
Joint Authors
Bjur, Kara A.
Cannon, Bryan C.
Fine, Anthony L.
Ritter, Matthew J.
Schueler, Kerry E.
Nemergut, Michael E.
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-3, 3 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-02-26
Country of Publication
Egypt
No. of Pages
3
Main Subjects
Abstract EN
Propylene glycol (PG) is a solvent commonly used in medications that, while benign at low doses, may cause toxicity in adults and children at high doses.
We describe a case and the physiologic sequelae of propylene glycol toxicity manifested in a critically ill adolescent male with refractory myoclonic status epilepticus aggressively treated with multiple PG-containing medications (lorazepam, phenobarbital, and pentobarbital)—all within accepted dosing guidelines and a total daily PG exposure previously recognized to be safe.
Hemodynamic measurements by bedside echocardiography during clinical toxicity are also reported.
Clinicians should have a high index of suspicion for propylene glycol toxicity in patients treated with PG-containing medications even when the total PG exposure is lower than currently accepted limits.
American Psychological Association (APA)
Bjur, Kara A.& Cannon, Bryan C.& Fine, Anthony L.& Ritter, Matthew J.& Schueler, Kerry E.& Nemergut, Michael E.. 2017. Propylene Glycol Toxicity in Adolescent with Refractory Myoclonic Status Epilepticus. Case Reports in Pediatrics،Vol. 2017, no. 2017, pp.1-3.
https://search.emarefa.net/detail/BIM-1149286
Modern Language Association (MLA)
Bjur, Kara A.…[et al.]. Propylene Glycol Toxicity in Adolescent with Refractory Myoclonic Status Epilepticus. Case Reports in Pediatrics No. 2017 (2017), pp.1-3.
https://search.emarefa.net/detail/BIM-1149286
American Medical Association (AMA)
Bjur, Kara A.& Cannon, Bryan C.& Fine, Anthony L.& Ritter, Matthew J.& Schueler, Kerry E.& Nemergut, Michael E.. Propylene Glycol Toxicity in Adolescent with Refractory Myoclonic Status Epilepticus. Case Reports in Pediatrics. 2017. Vol. 2017, no. 2017, pp.1-3.
https://search.emarefa.net/detail/BIM-1149286
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1149286