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Successful Oocyte Retrieval, Fertilization, and Clinical Pregnancy with Low Serum β-hCG on the Day of Oocyte Collection: A Reappraisal of the Definition of the Empty Follicle Syndrome
Joint Authors
Van De Velde, Nicole A.
Chatzicharalampous, Charalampos
Awonuga, A.
Source
Case Reports in Obstetrics and Gynecology
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-02-08
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Objective.
To describe a case of successful oocyte retrieval, fertilization and clinical pregnancy despite very low β-hCG level, twelve hours after ovulation trigger.
Design.
Case report.
Setting.
Academic medical center.
Patient.
A 38-year-old patient inadvertently administered 2,000 IU hCG for final oocyte maturation; serum hCG twelve hours later was 16 IU/L.
Interventions.
Effort to obtain and administer a booster dose of hCG over the next twenty-seven hours failed.
Main Outcome.
Successful oocyte retrieval.
Results.
Fourteen oocytes were retrieved of which twelve were in metaphase II and nine fertilized after intracytoplasmic sperm injection (ICSI).
Of these, eight embryos survived to day 5 and were subjected to preimplantation genetic screening (PGS) by comparative genomic hybridization (CGH).
Results were available the next day, three of the embryos were euploid and one was transferred on day 6.
Pregnancy was confirmed twelve days later and currently the patient has an ongoing singleton intrauterine pregnancy.
Conclusion.
Reproductive Endocrinology and Infertility specialists should be aware that final oocyte maturation could occur following injection of a lower dose of hCG with excellent fertilization rate and embryo development.
American Psychological Association (APA)
Van De Velde, Nicole A.& Chatzicharalampous, Charalampos& Awonuga, A.. 2020. Successful Oocyte Retrieval, Fertilization, and Clinical Pregnancy with Low Serum β-hCG on the Day of Oocyte Collection: A Reappraisal of the Definition of the Empty Follicle Syndrome. Case Reports in Obstetrics and Gynecology،Vol. 2020, no. 2020, pp.1-4.
https://search.emarefa.net/detail/BIM-1149288
Modern Language Association (MLA)
Van De Velde, Nicole A.…[et al.]. Successful Oocyte Retrieval, Fertilization, and Clinical Pregnancy with Low Serum β-hCG on the Day of Oocyte Collection: A Reappraisal of the Definition of the Empty Follicle Syndrome. Case Reports in Obstetrics and Gynecology No. 2020 (2020), pp.1-4.
https://search.emarefa.net/detail/BIM-1149288
American Medical Association (AMA)
Van De Velde, Nicole A.& Chatzicharalampous, Charalampos& Awonuga, A.. Successful Oocyte Retrieval, Fertilization, and Clinical Pregnancy with Low Serum β-hCG on the Day of Oocyte Collection: A Reappraisal of the Definition of the Empty Follicle Syndrome. Case Reports in Obstetrics and Gynecology. 2020. Vol. 2020, no. 2020, pp.1-4.
https://search.emarefa.net/detail/BIM-1149288
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1149288