Isotretinoin as a Possible Environmental Trigger to Autoimmunity in Genetically Susceptible Patients
Joint Authors
Schweiger, Bahareh
Nugroho, Jocelyn
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-3, 3 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-03-26
Country of Publication
Egypt
No. of Pages
3
Main Subjects
Abstract EN
Introduction.
Isotretinoin is commonly used to treat cystic acne.
Definitive mechanisms of action for isotretinoin are not known though despite many side effects having been documented.
Various case reports have noted autoimmune diseases succeeding isotretinoin treatment.
Case Report.
A 16-year-old female presents with symptoms of tremors, lack of focus, sleeplessness, emotional liability, bulging eyes, loose stools, heat intolerance, and missed menstrual periods.
Symptoms manifested shortly after the patient finished a course of oral isotretinoin treatment for acne.
Physical exam showed resting tremors, bilateral proptosis, hyperactivity, and rapid speech.
A diagnosis of Graves’ Disease was made by correlating symptoms, physical exam findings, ultrasound, and positive family history of autoimmune thyroid disease.
Conclusion.
Emergence of autoimmune thyroid diseases depends upon genetic predisposition and environmental triggers.
Mechanism of action for isotretinoin is not known but the drug may play a role in triggering autoimmunity in genetically susceptible individuals.
American Psychological Association (APA)
Nugroho, Jocelyn& Schweiger, Bahareh. 2017. Isotretinoin as a Possible Environmental Trigger to Autoimmunity in Genetically Susceptible Patients. Case Reports in Pediatrics،Vol. 2017, no. 2017, pp.1-3.
https://search.emarefa.net/detail/BIM-1149334
Modern Language Association (MLA)
Nugroho, Jocelyn& Schweiger, Bahareh. Isotretinoin as a Possible Environmental Trigger to Autoimmunity in Genetically Susceptible Patients. Case Reports in Pediatrics No. 2017 (2017), pp.1-3.
https://search.emarefa.net/detail/BIM-1149334
American Medical Association (AMA)
Nugroho, Jocelyn& Schweiger, Bahareh. Isotretinoin as a Possible Environmental Trigger to Autoimmunity in Genetically Susceptible Patients. Case Reports in Pediatrics. 2017. Vol. 2017, no. 2017, pp.1-3.
https://search.emarefa.net/detail/BIM-1149334
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1149334