Readministration of Cancer Drugs in a Patient with Chemorefractory Metastatic Colorectal Cancer
Joint Authors
Kawagoe, Tetsuro
Ikeda, Go
Oshiro, Yu
Maruki, Yuta
Kaneko, Keiko
Iwakiri, Katsuhiko
Source
Case Reports in Oncological Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-06-23
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
A 63-year-old woman was admitted to our institution for severe pain in her right lower abdomen caused by the perforation of cecal cancer.
She underwent emergency surgery, from which she was diagnosed with cecal carcinoma with liver, lung, and lymph node metastases.
As she was taking aspirin to prevent cerebral infarction, anti-vascular endothelial growth factor (receptor) antibody and regorafenib therapy were not used.
Thus, we started a modified FOLFOX 6+cetuximab regimen.
This first-line treatment initially achieved a partial response (PR), but she then developed progressive disease (PD) after 14 months.
We changed the regimen to FOLFIRI, followed by trifluridine/tipiracil, but her progression-free survival periods were 2.7 months and 1 month, respectively.
Although we cycled through the available array of standard cancer drugs, the patient showed a good performance status, and some benefit from treatment still seemed plausible.
We readministered the 5-fluorouracil oral preparation S-1, which maintained stable disease (SD) for 7 months.
After PD emerged, we readministered the anti-epidermal growth factor receptor (EGFR) antibody panitumumab for 7.5 months of SD.
Finally, 39 months after her diagnosis, she died from rapidly progressing disease.
However, her relatively long survival implies that readministering drugs similar to those used in previous regimens might benefit patients with metastatic colorectal cancer.
American Psychological Association (APA)
Kawagoe, Tetsuro& Ikeda, Go& Oshiro, Yu& Maruki, Yuta& Kaneko, Keiko& Iwakiri, Katsuhiko. 2020. Readministration of Cancer Drugs in a Patient with Chemorefractory Metastatic Colorectal Cancer. Case Reports in Oncological Medicine،Vol. 2020, no. 2020, pp.1-4.
https://search.emarefa.net/detail/BIM-1149342
Modern Language Association (MLA)
Kawagoe, Tetsuro…[et al.]. Readministration of Cancer Drugs in a Patient with Chemorefractory Metastatic Colorectal Cancer. Case Reports in Oncological Medicine No. 2020 (2020), pp.1-4.
https://search.emarefa.net/detail/BIM-1149342
American Medical Association (AMA)
Kawagoe, Tetsuro& Ikeda, Go& Oshiro, Yu& Maruki, Yuta& Kaneko, Keiko& Iwakiri, Katsuhiko. Readministration of Cancer Drugs in a Patient with Chemorefractory Metastatic Colorectal Cancer. Case Reports in Oncological Medicine. 2020. Vol. 2020, no. 2020, pp.1-4.
https://search.emarefa.net/detail/BIM-1149342
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1149342