Network Pharmacology-Based Study on the Mechanism of Bushen-Jianpi Decoction in Liver Cancer Treatment
Joint Authors
Wu, Rong
Li, Xiao-Yan
Wang, Wen-Hai
Cai, Fei-Fei
Chen, Xiao-Le
Yang, Meng-Die
Pan, Qiu-Sha
Zhou, Rong-Yao
Su, Shi-Bing
Chen, Qi-long
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-03-19
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
To investigate the mechanism of a Bushen-Jianpi decoction (BSJPD) in liver cancer (LC) treatment, we analyzed clinical therapy data, conducted network pharmacology analysis, and performed pharmacological experimental verification in vitro and in vivo.
The univariate analysis of clinical therapy showed that the BSJPD was protective factor (p < 0.05).
The network pharmacology analysis showed that 9 compounds were important nodes of BSJPD-LC therapy network.
In experimental verification, the rate of apoptosis increased in the liver tumors of mice treated with the BSJPD (p < 0.05); drug serum with 20 % BSJPD inhibited cell viability (p < 0.05) and reduced the expression of PI3K, the Bcl-xL/BAD ratio, and the levels of p53 and p-Akt in HepG2 cells.
Moreover, licochalcone A, alisol B, and hederagenin inhibited cell viability (p < 0.05), induced cell apoptosis (p < 0.01), reduced p-Akt levels, and increased cleaved-CASP3 (p < 0.05) and p53 expression levels in HepG2 cells.
These data suggest that the BSJPD prolongs the survival of LC patients and induces apoptosis and that it may be associated with the regulation of PI3K, Akt, p53, CASP3, and Bcl-xL/BAD expression.
American Psychological Association (APA)
Wu, Rong& Li, Xiao-Yan& Wang, Wen-Hai& Cai, Fei-Fei& Chen, Xiao-Le& Yang, Meng-Die…[et al.]. 2019. Network Pharmacology-Based Study on the Mechanism of Bushen-Jianpi Decoction in Liver Cancer Treatment. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1149352
Modern Language Association (MLA)
Wu, Rong…[et al.]. Network Pharmacology-Based Study on the Mechanism of Bushen-Jianpi Decoction in Liver Cancer Treatment. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-13.
https://search.emarefa.net/detail/BIM-1149352
American Medical Association (AMA)
Wu, Rong& Li, Xiao-Yan& Wang, Wen-Hai& Cai, Fei-Fei& Chen, Xiao-Le& Yang, Meng-Die…[et al.]. Network Pharmacology-Based Study on the Mechanism of Bushen-Jianpi Decoction in Liver Cancer Treatment. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1149352
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1149352