PD-1 Inhibitor Therapy in a Patient with Preexisting P-ANCA Vasculitis: A Case Report and Review of the Literature
Joint Authors
Ramos, Amanda
del Carmen, Marcela
Yeku, Oladapo
Source
Case Reports in Oncological Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-08-31
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Background.
Recurrent endometrial cancer after definitive therapy is a lethal disease.
Recently, immune checkpoint inhibitors (ICI) have improved the management of mismatch repair-deficient (MSI-H) endometrial cancer.
Autoimmune side effects are known to occur with ICI.
As a result, patients with preexisting autoimmune diseases are excluded from studies involving these drugs.
This has led to challenges in clinical practice regarding the use of ICI in otherwise eligible patients with underlying autoimmune disease.
Case Presentation.
We present the case of an 81-year-old woman with an underlying autoimmune vasculitis and recurrent, metastatic endometrial adenocarcinoma with microsatellite instability, who was treated with an immune checkpoint inhibitor.
This patient received pembrolizumab, an immune checkpoint inhibitor that targets the programmed cell death-1 immune checkpoint.
Ultimately, she was treated for 4 months with pembrolizumab and benefited from stable disease during this period.
She remained asymptomatic from her underlying autoimmune P-ANCA vasculitis.
A review of the scientific literature reveals several cases of the successful use of immune checkpoint inhibitors in patients with autoimmune diseases, including systemic lupus erythematosus, rheumatoid arthritis, and inflammatory bowel disease.
Conclusion.
This is one of the first reports of a patient with an underlying autoimmune vasculitis successfully treated with an immune checkpoint inhibitor without exacerbating her underlying autoimmune condition.
Carefully selected patients with underlying autoimmune vasculitis can be safely treated with ICI.
American Psychological Association (APA)
Ramos, Amanda& del Carmen, Marcela& Yeku, Oladapo. 2020. PD-1 Inhibitor Therapy in a Patient with Preexisting P-ANCA Vasculitis: A Case Report and Review of the Literature. Case Reports in Oncological Medicine،Vol. 2020, no. 2020, pp.1-5.
https://search.emarefa.net/detail/BIM-1149365
Modern Language Association (MLA)
Ramos, Amanda…[et al.]. PD-1 Inhibitor Therapy in a Patient with Preexisting P-ANCA Vasculitis: A Case Report and Review of the Literature. Case Reports in Oncological Medicine No. 2020 (2020), pp.1-5.
https://search.emarefa.net/detail/BIM-1149365
American Medical Association (AMA)
Ramos, Amanda& del Carmen, Marcela& Yeku, Oladapo. PD-1 Inhibitor Therapy in a Patient with Preexisting P-ANCA Vasculitis: A Case Report and Review of the Literature. Case Reports in Oncological Medicine. 2020. Vol. 2020, no. 2020, pp.1-5.
https://search.emarefa.net/detail/BIM-1149365
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1149365