Rare Presentation of Cardiotoxicity Related to 5-Fluorouracil
Joint Authors
Barrera, Francisco
Murvelashvili, Natia
Charkviani, Mariam
Sharma, Alisha
Eldin, Randa Sharag
Nabil, Nur Un Nisa
Source
Case Reports in Oncological Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-07-21
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
5-Fluorouracil (5-FU) is a chemotherapeutic agent frequently used for the treatment of solid tumors.
In a few cases, 5-FU can be associated with coronary vasospasm, cardiac ischemia, or life-threatening arrhythmias.
Recognition of 5-FU cardiotoxicity is clinically important as after the rapid sensation of therapy, cardiotoxicity can be completely reversible, and on the other hand, readministration may lead to serious damage of the heart and even death.
A 70-year-old male came to the emergency department (ED) with chest pain which started while receiving an infusion of 5-FU.
The patient did not have a personal history or risk factors of coronary artery disease and his electrocardiogram (ECG) before starting chemotherapy was completely normal.
In the ED, his ECG had ischemic changes, troponin was elevated, and echocardiogram showed anterior wall hypokinesis.
However, emergent coronary angiogram did not reveal any acute coronary occlusion.
5-FU-induced cardiotoxicity was suspected; the patient was admitted to a progressive care unit for close monitoring and infusion of calcium channel blockers was initiated.
The patient’s symptoms and ECG findings gradually resolved, and two days later on discharge, patient was chest pain free and ECG was normal.
This case supports the vasospastic hypothesis of 5-FU cardiac toxicity, describes its clinical course, and emphasizes the importance of better awareness and early recognition of the rare side effect as it may allow physicians to reduce the risk of life-threatening complications.
American Psychological Association (APA)
Charkviani, Mariam& Murvelashvili, Natia& Barrera, Francisco& Sharma, Alisha& Eldin, Randa Sharag& Nabil, Nur Un Nisa. 2020. Rare Presentation of Cardiotoxicity Related to 5-Fluorouracil. Case Reports in Oncological Medicine،Vol. 2020, no. 2020, pp.1-4.
https://search.emarefa.net/detail/BIM-1149395
Modern Language Association (MLA)
Charkviani, Mariam…[et al.]. Rare Presentation of Cardiotoxicity Related to 5-Fluorouracil. Case Reports in Oncological Medicine No. 2020 (2020), pp.1-4.
https://search.emarefa.net/detail/BIM-1149395
American Medical Association (AMA)
Charkviani, Mariam& Murvelashvili, Natia& Barrera, Francisco& Sharma, Alisha& Eldin, Randa Sharag& Nabil, Nur Un Nisa. Rare Presentation of Cardiotoxicity Related to 5-Fluorouracil. Case Reports in Oncological Medicine. 2020. Vol. 2020, no. 2020, pp.1-4.
https://search.emarefa.net/detail/BIM-1149395
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1149395