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The Partial Duplication of the 5′ Segment of KMT2A Revealed KMT2A-MLLT10 Rearrangement in a Boy with Acute Myeloid Leukemia
Joint Authors
Nanmoku, Toru
Hosaka, Sho
Yamaki, Yuni
Fukushima, Hiroko
Kiyokawa, Nobutaka
Fukushima, Takashi
Sumazaki, Ryo
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-3, 3 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-12-28
Country of Publication
Egypt
No. of Pages
3
Main Subjects
Abstract EN
The duplication of 5′ segment of KMT2A is a rare molecular event in childhood leukemia, and the influence on prognosis is unknown.
Here, we report on a boy who developed acute monocytic leukemia.
Fluorescence in situ hybridization revealed the duplication of the 5′ segment with 2 normal alleles at KMT2A which was eventually found to be fused with MLLT10.
Chemotherapy promptly induced the first complete remission in the patient at our facility, and the patient remained in first complete remission with negative minimal residual disease at 3.5 years from diagnosis.
Our case is similar to two previously reported patients who had partial duplication of the 5′ segment of KMT2A with a KMT2A-MLLT10 rearrangement.
Further studies and experience with this cryptic translocation may shed more light on the management of acute myeloid leukemia.
American Psychological Association (APA)
Fukushima, Hiroko& Nanmoku, Toru& Hosaka, Sho& Yamaki, Yuni& Kiyokawa, Nobutaka& Fukushima, Takashi…[et al.]. 2017. The Partial Duplication of the 5′ Segment of KMT2A Revealed KMT2A-MLLT10 Rearrangement in a Boy with Acute Myeloid Leukemia. Case Reports in Pediatrics،Vol. 2017, no. 2017, pp.1-3.
https://search.emarefa.net/detail/BIM-1149401
Modern Language Association (MLA)
Fukushima, Hiroko…[et al.]. The Partial Duplication of the 5′ Segment of KMT2A Revealed KMT2A-MLLT10 Rearrangement in a Boy with Acute Myeloid Leukemia. Case Reports in Pediatrics No. 2017 (2017), pp.1-3.
https://search.emarefa.net/detail/BIM-1149401
American Medical Association (AMA)
Fukushima, Hiroko& Nanmoku, Toru& Hosaka, Sho& Yamaki, Yuni& Kiyokawa, Nobutaka& Fukushima, Takashi…[et al.]. The Partial Duplication of the 5′ Segment of KMT2A Revealed KMT2A-MLLT10 Rearrangement in a Boy with Acute Myeloid Leukemia. Case Reports in Pediatrics. 2017. Vol. 2017, no. 2017, pp.1-3.
https://search.emarefa.net/detail/BIM-1149401
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1149401