An Atypical Presentation of Pediatric Acute Neuropsychiatric Syndrome Responding to Plasmapheresis Treatment
Joint Authors
Jackson, Hannah
Singh, Umesh
Griffey, Marcus
Sorter, Michael
Bernstein, Jonathan A.
Barzman, Drew H.
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-06-28
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Here we report a case of a 15-year-old female who had originally been diagnosed and treated unsuccessfully for schizophrenia, psychosis, severe anxiety, and depression.
More in-depth history revealed an abrupt onset of her symptoms with remote acute infections and many exhibited characteristics of obsessive compulsive disorder with rituals.
Work-up for underlying infectious, immunodeficiency, and autoimmune causes was unrevealing except for very high levels of anti-neuronal antibodies which have been linked to Pediatric Acute-onset Neuropsychiatric Syndrome (PANS).
Treatment options were discussed with the family and it was decided to use a course of plasmapheresis based on previous studies demonstrating efficacy and its safety profile.
After course of therapy, there was a dramatic resolution of her psychosis, OCD traits, and anxiety.
She was able to stop all of her antipsychotic and anxiety medications and resume many of her previous normal daily activities.
The effect of this treatment has been sustained to the present time.
This case emphasizes the importance of exploring nontraditional treatments for severe, treatment-resistant mental illness which requires a multidisciplinary approach.
Further research is warranted in larger populations to investigate pathomechanisms and treatment of PANs/PANDAs.
American Psychological Association (APA)
Barzman, Drew H.& Jackson, Hannah& Singh, Umesh& Griffey, Marcus& Sorter, Michael& Bernstein, Jonathan A.. 2018. An Atypical Presentation of Pediatric Acute Neuropsychiatric Syndrome Responding to Plasmapheresis Treatment. Case Reports in Psychiatry،Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1149402
Modern Language Association (MLA)
Barzman, Drew H.…[et al.]. An Atypical Presentation of Pediatric Acute Neuropsychiatric Syndrome Responding to Plasmapheresis Treatment. Case Reports in Psychiatry No. 2018 (2018), pp.1-5.
https://search.emarefa.net/detail/BIM-1149402
American Medical Association (AMA)
Barzman, Drew H.& Jackson, Hannah& Singh, Umesh& Griffey, Marcus& Sorter, Michael& Bernstein, Jonathan A.. An Atypical Presentation of Pediatric Acute Neuropsychiatric Syndrome Responding to Plasmapheresis Treatment. Case Reports in Psychiatry. 2018. Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1149402
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1149402