Response to IpilimumabNivolumab Rechallenge and BRAF InhibitorMEK Inhibitor Rechallenge in a Patient with Advanced Metastatic Melanoma Previously Treated with BRAF Targeted Therapy and Immunotherapy
Joint Authors
Myrdal, Caitlyn N.
Sundararajan, Srinath
Source
Case Reports in Oncological Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-06-25
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Little is known about the optimal sequencing of targeted therapy and immunotherapy in the treatment of patients with BRAFV600-mutated metastatic melanoma.
BRAF/MEK inhibition often has the benefit of rapid disease regression; however, resistance is frequently seen with long-term use.
Treatment with immune checkpoint inhibitors offers the potential for long-term response but displays a lower rate of objective response.
The benefit of synergy between therapies is apparent; however, there is limited data regarding optimal sequencing in the treatment of advanced melanoma.
We present the case of a 62-year-old gentleman with advanced BRAFV600-mutated melanoma who followed an unconventional treatment path.
After progressing on single-agent vemurafenib, he had response to multiple modalities of immunotherapy before progression.
After, he had a substantial response to multiple BRAF/MEK inhibitor rechallenges before developing resistance.
The patient is now stable after a retrial of combination immunotherapy.
Our case illustrates that with the right sequencing of therapy, meaningful clinical responses can be elicited with rechallenging of targeted therapy and immunotherapy in metastatic melanoma.
American Psychological Association (APA)
Myrdal, Caitlyn N.& Sundararajan, Srinath. 2020. Response to IpilimumabNivolumab Rechallenge and BRAF InhibitorMEK Inhibitor Rechallenge in a Patient with Advanced Metastatic Melanoma Previously Treated with BRAF Targeted Therapy and Immunotherapy. Case Reports in Oncological Medicine،Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1149406
Modern Language Association (MLA)
Myrdal, Caitlyn N.& Sundararajan, Srinath. Response to IpilimumabNivolumab Rechallenge and BRAF InhibitorMEK Inhibitor Rechallenge in a Patient with Advanced Metastatic Melanoma Previously Treated with BRAF Targeted Therapy and Immunotherapy. Case Reports in Oncological Medicine No. 2020 (2020), pp.1-6.
https://search.emarefa.net/detail/BIM-1149406
American Medical Association (AMA)
Myrdal, Caitlyn N.& Sundararajan, Srinath. Response to IpilimumabNivolumab Rechallenge and BRAF InhibitorMEK Inhibitor Rechallenge in a Patient with Advanced Metastatic Melanoma Previously Treated with BRAF Targeted Therapy and Immunotherapy. Case Reports in Oncological Medicine. 2020. Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1149406
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1149406