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Transient Ischemic Attack and Ischemic Stroke in Danon Disease with Formation of Left Ventricular Apical Thrombus despite Normal Systolic Function
Joint Authors
Tsuda, Takeshi
Shillingford, Amanda J.
Vetter, Jane
Kandula, Vinay
Jain, Badal
Temple, Joel
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-09-20
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Danon disease is a rare X-linked dominant skeletal and cardiac muscle disorder presenting with hypertrophic cardiomyopathy, Wolf-Parkinson-White syndrome, skeletal myopathy, and mild intellectual disability.
Early morbidity and mortality due to heart failure or sudden death are known in Danon disease, more in males than in females.
Here, we present a 17-year-old female adolescent with Danon disease and severe concentric hypertrophy with normal left ventricular (LV) systolic function, who has been complaining of intermittent headache and weakness for about 3 years, initially diagnosed with hemiplegic migraine.
Subsequently, her neurological manifestation progressed to transient ischemic attack (TIA) and eventually to ischemic stroke confirmed by CT scan with 1-day history of expressive aphasia followed by persistent left side weakness and numbness.
Detailed echocardiogram for the first time revealed a small LV apical thrombus with unchanged severe biventricular hypertrophy and normal systolic function.
This unexpected LV apical thrombus may be associated with a wide spectrum of neurological deficits ranging from TIA to ischemic stroke in Danon disease.
Possibility of cerebral ischemic events should be suspected in Danon disease when presenting with neurological deficits even with normal systolic function.
Careful assessment for LV apical thrombus is warranted in such cases.
American Psychological Association (APA)
Tsuda, Takeshi& Shillingford, Amanda J.& Vetter, Jane& Kandula, Vinay& Jain, Badal& Temple, Joel. 2017. Transient Ischemic Attack and Ischemic Stroke in Danon Disease with Formation of Left Ventricular Apical Thrombus despite Normal Systolic Function. Case Reports in Pediatrics،Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1149413
Modern Language Association (MLA)
Tsuda, Takeshi…[et al.]. Transient Ischemic Attack and Ischemic Stroke in Danon Disease with Formation of Left Ventricular Apical Thrombus despite Normal Systolic Function. Case Reports in Pediatrics No. 2017 (2017), pp.1-5.
https://search.emarefa.net/detail/BIM-1149413
American Medical Association (AMA)
Tsuda, Takeshi& Shillingford, Amanda J.& Vetter, Jane& Kandula, Vinay& Jain, Badal& Temple, Joel. Transient Ischemic Attack and Ischemic Stroke in Danon Disease with Formation of Left Ventricular Apical Thrombus despite Normal Systolic Function. Case Reports in Pediatrics. 2017. Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1149413
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1149413