Preventive Effect of the Herbal Preparation, HemoHIM, on Cisplatin-Induced Immune Suppression
Joint Authors
Kim, Seul-Ki
Kwon, Da-Ae
Lee, Hak Sung
Kim, Hyun Kyu
Kim, Won-Ki
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-03-20
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
We determined the functional effect of the herbal preparation, HemoHIM, on the immune system, by examining the immunomodulatory activities of HemoHIM using immunocompromised mice.
In this study, to examine the effect on the restoration of immune cells and balance in the immune system, we utilized a cisplatin-induced immunosuppression mouse model.
Mice were injected intraperitoneally with cisplatin, an immunosuppressive anticancer, and then received oral doses of 100, 250, and 500 mg/kg of HemoHIM for 14 days.
The HemoHIM prevented the cisplatin-induced loss of body and organ weight.
In terms of innate immunity, natural killer (NK) cell activity and phagocytosis increased in the HemoHIM group compared to the cisplatin control group.
The HemoHIM group also showed a significantly higher expression of Th1-mediated cytokines (interferon gamma (IFN-γ), interleukin-2 (IL-2), and tumor necrosis factor alpha (TNF-α)) and inhibited the production of Th2-mediated cytokine interleukin-4 (IL-4) compared to cisplatin control group.
These findings indicate that HemoHIM enhances immune activity by modulating immune cell activity and cytokine secretion in immune-suppressed mice.
American Psychological Association (APA)
Kim, Seul-Ki& Kwon, Da-Ae& Lee, Hak Sung& Kim, Hyun Kyu& Kim, Won-Ki. 2019. Preventive Effect of the Herbal Preparation, HemoHIM, on Cisplatin-Induced Immune Suppression. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1149427
Modern Language Association (MLA)
Kim, Seul-Ki…[et al.]. Preventive Effect of the Herbal Preparation, HemoHIM, on Cisplatin-Induced Immune Suppression. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1149427
American Medical Association (AMA)
Kim, Seul-Ki& Kwon, Da-Ae& Lee, Hak Sung& Kim, Hyun Kyu& Kim, Won-Ki. Preventive Effect of the Herbal Preparation, HemoHIM, on Cisplatin-Induced Immune Suppression. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1149427
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1149427