Metastatic Small-Cell Lung Cancer Presenting as Primary Adrenal Insufficiency
Joint Authors
Esperti, Shawn
Stoelting, Austen
Scibelli, Nicolina
Moccia, David
Patel, Dveet
Haughton, Michael
Mangano, Andrew
Source
Case Reports in Oncological Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-03-19
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
A 40-year-old male smoker with HIV was admitted for cough, hypotension, and abdominal pain for 5 days.
Chest radiography showed a right lower lobe consolidation.
CT of the chest, abdomen, and pelvis revealed paratracheal adenopathy, a 5.8×4.5 cm mass invading the right bronchus intermedius, and dense bilateral adrenal masses, measuring 5.4×4.0 cm on the right and 4.8×2.0 cm on the left.
Laboratory studies showed white blood cell count of 18.5 K/mm3, sodium of 131 mmol/L, creatinine of 1.6 mg/dL, and CD4 count of 567 cells/mm3.
The random morning cortisol level was 7.0 μg/dL, the ACTH stimulation test yielded inappropriate response, and a random serum ACTH was elevated at 83.4 pg/mL.
MRI brain revealed no pituitary adenoma confirming primary adrenal insufficiency.
The adrenal CT washout study was consistent with solid mass content, concerning for metastasis.
Bronchoscopy with endobronchial mass and paratracheal lymph node biopsy confirmed small-cell lung cancer (SCLC).
Intravenous steroids, 100 mg hydrocortisone every 8 hours, improved his hypotension and abdominal pain.
PET scan revealed metabolically active right paratracheal mass, right hilar mass, and bilateral adrenal masses.
Treatment included palliative chemotherapy consisting of carboplatin/etoposide/atezolizumab and chest radiation.
We present this novel case to demonstrate SCLC’s ability to cause primary adrenal insufficiency, as well as evaluate clinical response to chemotherapeutics.
American Psychological Association (APA)
Esperti, Shawn& Stoelting, Austen& Scibelli, Nicolina& Moccia, David& Patel, Dveet& Haughton, Michael…[et al.]. 2020. Metastatic Small-Cell Lung Cancer Presenting as Primary Adrenal Insufficiency. Case Reports in Oncological Medicine،Vol. 2020, no. 2020, pp.1-4.
https://search.emarefa.net/detail/BIM-1149457
Modern Language Association (MLA)
Esperti, Shawn…[et al.]. Metastatic Small-Cell Lung Cancer Presenting as Primary Adrenal Insufficiency. Case Reports in Oncological Medicine No. 2020 (2020), pp.1-4.
https://search.emarefa.net/detail/BIM-1149457
American Medical Association (AMA)
Esperti, Shawn& Stoelting, Austen& Scibelli, Nicolina& Moccia, David& Patel, Dveet& Haughton, Michael…[et al.]. Metastatic Small-Cell Lung Cancer Presenting as Primary Adrenal Insufficiency. Case Reports in Oncological Medicine. 2020. Vol. 2020, no. 2020, pp.1-4.
https://search.emarefa.net/detail/BIM-1149457
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1149457