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Metabolic and Epigenetic Action Mechanisms of Antidiabetic Medicinal Plants
Joint Authors
Zaid, Hilal
Saad, Bashar
Shanak, Siba
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-18, 18 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-05-05
Country of Publication
Egypt
No. of Pages
18
Main Subjects
Abstract EN
Diabetes is a predominant metabolic disease nowadays due to the off-beam lifestyle of diet and reduced physical activity.
Complications of the illness include the gene-environment interactions and the downstream genetic and epigenetic consequences, e.g., cardiovascular diseases, tumor progression, retinopathy, nephropathy, neuropathy, polydipsia, polyphagia, polyuria, and weight loss.
This review sheds the light on the mechanistic insights of antidiabetic medicinal plants in targeting key organs and tissues involved in regulating blood glucose homeostasis including the pancreas, liver, muscles, adipose tissues, and glucose absorption in the intestine.
Diabetes is also involved in modulating major epigenetic pathways such as DNA methylation and histone modification.
In this respect, we will discuss the phytochemicals as current and future epigenetic drugs in the treatment of diabetes.
In addition, several proteins are common targets for the treatment of diabetes.
Some phytochemicals are expected to directly interact with these targets.
We lastly uncover modeling studies that predict such plausible interactions.
In conclusion, this review article presents the mechanistic insight of phytochemicals in the treatment of diabetes by combining both the cellular systems biology and molecular modeling.
American Psychological Association (APA)
Shanak, Siba& Saad, Bashar& Zaid, Hilal. 2019. Metabolic and Epigenetic Action Mechanisms of Antidiabetic Medicinal Plants. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-18.
https://search.emarefa.net/detail/BIM-1149470
Modern Language Association (MLA)
Shanak, Siba…[et al.]. Metabolic and Epigenetic Action Mechanisms of Antidiabetic Medicinal Plants. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-18.
https://search.emarefa.net/detail/BIM-1149470
American Medical Association (AMA)
Shanak, Siba& Saad, Bashar& Zaid, Hilal. Metabolic and Epigenetic Action Mechanisms of Antidiabetic Medicinal Plants. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-18.
https://search.emarefa.net/detail/BIM-1149470
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1149470