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Nephroprotective Role of Beta vulgaris L. Root Extract against Chlorpyrifos-Induced Renal Injury in Rats
Joint Authors
Alarifi, Saud
Alkahtani, Saad
Albasher, Gadah
Almeer, Rafa
Farhood, Manal
Al-Otibi, Fatimah O.
Alkubaisi, Noorah
Rizwana, Humaira
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-11-22
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Organophosphorus pesticides (OPs) are widely used for agricultural and housekeeping purposes.
Exposure to OPs is associated with the progression of several health issues.
Antioxidant agents may be powerful candidates to minimise adverse reactions caused by OPs.
The aim of the present study was to evaluate the nephroprotective effects of red beetroot extract (RBR) against chlorpyrifos- (CPF-) induced renal impairments.
CPF induced kidney dysfunction, as demonstrated by changes in serum creatinine and urea levels.
Moreover, CPF exposure induced oxidative stress in the kidneys as determined by increased malondialdehyde and nitric oxide levels, decreased glutathione content, decreased catalase, superoxide dismutase, glutathione peroxidase, and glutathione reductase activities, and decreased nuclear factor (erythroid-derived 2)-like-2 factor expression.
In addition, CPF induced inflammation in renal tissue as evidenced by increased release of tumor necrosis factor-alpha and interleukin-1β and upregulation of inducible nitric oxide synthase.
Furthermore, CPF promoted cell death as demonstrated by decreased Bcl-2 and increased Bax and caspase-3 levels.
Treatment with RBR one hour prior to CPF treatment blocked the effects observed in response to CPF alone.
Our results suggest that RBR could be used to alleviate CPF-induced nephrotoxicity through antioxidant, anti-inflammatory, and antiapoptotic activities.
American Psychological Association (APA)
Albasher, Gadah& Almeer, Rafa& Alarifi, Saud& Alkahtani, Saad& Farhood, Manal& Al-Otibi, Fatimah O.…[et al.]. 2019. Nephroprotective Role of Beta vulgaris L. Root Extract against Chlorpyrifos-Induced Renal Injury in Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1149474
Modern Language Association (MLA)
Albasher, Gadah…[et al.]. Nephroprotective Role of Beta vulgaris L. Root Extract against Chlorpyrifos-Induced Renal Injury in Rats. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1149474
American Medical Association (AMA)
Albasher, Gadah& Almeer, Rafa& Alarifi, Saud& Alkahtani, Saad& Farhood, Manal& Al-Otibi, Fatimah O.…[et al.]. Nephroprotective Role of Beta vulgaris L. Root Extract against Chlorpyrifos-Induced Renal Injury in Rats. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1149474
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1149474