![](/images/graphics-bg.png)
Pulmonary Alveolar Proteinosis in Setting of Inhaled Toxin Exposure and Chronic Substance Abuse
Joint Authors
Li, Meirui
Schell, Miranda
Davis, Clive
Naqvi, Asghar
Alowami, Salem
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-01-23
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Pulmonary alveolar proteinosis (PAP) is a rare lung disorder in which defects in alveolar macrophage maturation or function lead to the accumulation of proteinaceous surfactant in alveolar space, resulting in impaired gas exchange and hypoxemia.
PAP is categorized into three types: hereditary, autoimmune, and secondary.
We report a case of secondary PAP in a 47-year-old man, whose risk factors include occupational exposure to inhaled toxins, especially aluminum dust, the use of anabolic steroids, and alcohol abuse, which in mice leads to alveolar macrophage dysfunction through a zinc-dependent mechanism that inhibits granulocyte macrophage-colony stimulating factor (GM-CSF) receptor signalling.
Although the rarity and vague clinical presentation of PAP can pose diagnostic challenges, clinician awareness of PAP risk factors may facilitate the diagnostic process and lead to more prompt treatment.
American Psychological Association (APA)
Li, Meirui& Alowami, Salem& Schell, Miranda& Davis, Clive& Naqvi, Asghar. 2018. Pulmonary Alveolar Proteinosis in Setting of Inhaled Toxin Exposure and Chronic Substance Abuse. Case Reports in Pulmonology،Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1149480
Modern Language Association (MLA)
Li, Meirui…[et al.]. Pulmonary Alveolar Proteinosis in Setting of Inhaled Toxin Exposure and Chronic Substance Abuse. Case Reports in Pulmonology No. 2018 (2018), pp.1-5.
https://search.emarefa.net/detail/BIM-1149480
American Medical Association (AMA)
Li, Meirui& Alowami, Salem& Schell, Miranda& Davis, Clive& Naqvi, Asghar. Pulmonary Alveolar Proteinosis in Setting of Inhaled Toxin Exposure and Chronic Substance Abuse. Case Reports in Pulmonology. 2018. Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1149480
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1149480