Aiweixin, a Traditional Uyghur Medicinal Formula, Extends the Lifespan of Caenorhabditis elegans
Joint Authors
Zhu, Bing-gen
Jo, Kayama
Yang, Ping
Tohti, Jurat
Fei, Jian
Abudukerim, Kaisaier
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-01-13
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Aiweixin (AWX) is a traditional Uyghur medicine prescription, which has been used to treat senile diseases for a long time.
We investigate whether the AWX extends the lifespan of Caenorhabditis elegans.
The AWX decoction was the conventional product for clinical use.
The wild-type Caenorhabditis elegans (N2) and mutational worms, daf-16(mu86), glp-1(e2141), daf-2(e1370), and eat-2(ad465), were applied for the lifespan analysis.
We found that the lifespan of the N2 adults' worm received 0.005 and 0.01 volume of AWX/total volume was extended significantly, compared to the control without treatment of AWX.
The AWX at 0.01 volume of AWX/total volume significantly prolonged the life of both mutational worms, daf-16 (mu86) and eat-2(ad465), but did not increase the lifespan of the mutational worms, daf-2(e1370) and glp-1(e2141).
These results indicated that the AWX significantly extended the lifespan of wild-type nematodes, and the life extension effect of AWX was related to the germline longevity pathway and IIS signaling pathway but independent of DAF-16/FOXO.
American Psychological Association (APA)
Zhu, Bing-gen& Jo, Kayama& Yang, Ping& Tohti, Jurat& Fei, Jian& Abudukerim, Kaisaier. 2019. Aiweixin, a Traditional Uyghur Medicinal Formula, Extends the Lifespan of Caenorhabditis elegans. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-5.
https://search.emarefa.net/detail/BIM-1149535
Modern Language Association (MLA)
Zhu, Bing-gen…[et al.]. Aiweixin, a Traditional Uyghur Medicinal Formula, Extends the Lifespan of Caenorhabditis elegans. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-5.
https://search.emarefa.net/detail/BIM-1149535
American Medical Association (AMA)
Zhu, Bing-gen& Jo, Kayama& Yang, Ping& Tohti, Jurat& Fei, Jian& Abudukerim, Kaisaier. Aiweixin, a Traditional Uyghur Medicinal Formula, Extends the Lifespan of Caenorhabditis elegans. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-5.
https://search.emarefa.net/detail/BIM-1149535
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1149535