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Ginsenoside Re Improves Isoproterenol-Induced Myocardial Fibrosis and Heart Failure in Rats
Joint Authors
Yu, Xiao-feng
Xu, Hua-li
Zhao, Xue-zhong
Wang, Quan-wei
Sui, Da-yuan
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-01-01
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Objective.
Panax ginseng is used widely for treatment of cardiovascular disorders in China.
Ginsenoside Re is the main chemical component of P.
ginseng.
We aimed to investigate the protective effect of ginsenoside Re on isoproterenol-induced myocardial fibrosis and heart failure in rats.
Methods.
A model of myocardial fibrosis and heart failure was established by once-daily subcutaneous injection of isoproterenol (5 mg/kg/day) to rats for 7 days.
Simultaneously, rats were orally administrated ginsenoside Re (5 or 20 mg/kg) or vehicle daily for 4 weeks.
Results.
Isoproterenol enhanced the heart weight, myocardial fibrosis, and hydroxyproline content in rat hearts.
Ginsenoside Re inhibited (at least in part) the isoproterenol-induced increase in heart weight, myocardial fibrosis, and hydroxyproline content.
Compared with the isoproterenol group, treatment with ginsenoside Re ameliorated changes in left ventricular systolic pressure, left ventricular end diastolic pressure, and the positive and negative maximal values of the first derivative of left ventricular pressure.
Ginsenoside Re administration also resulted in decreased expression of transforming growth factor (TGF)-β1 in serum and decreased expression of Smad3 and collagen I in heart tissue.
Conclusion.
Ginsenoside Re can improve isoproterenol-induced myocardial fibrosis and heart failure by regulation of the TGF-β1/Smad3 pathway.
American Psychological Association (APA)
Wang, Quan-wei& Yu, Xiao-feng& Xu, Hua-li& Zhao, Xue-zhong& Sui, Da-yuan. 2019. Ginsenoside Re Improves Isoproterenol-Induced Myocardial Fibrosis and Heart Failure in Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1149557
Modern Language Association (MLA)
Wang, Quan-wei…[et al.]. Ginsenoside Re Improves Isoproterenol-Induced Myocardial Fibrosis and Heart Failure in Rats. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1149557
American Medical Association (AMA)
Wang, Quan-wei& Yu, Xiao-feng& Xu, Hua-li& Zhao, Xue-zhong& Sui, Da-yuan. Ginsenoside Re Improves Isoproterenol-Induced Myocardial Fibrosis and Heart Failure in Rats. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1149557
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1149557