Sodium-Glucose Cotransporter 2 Inhibitors Improve Chronic Diabetic Macular Edema
Joint Authors
Yokote, Koutaro
Baba, Takayuki
Tatsumi, Tomoaki
Takatsuna, Yoko
Koshizaka, Masaya
Yamamoto, Shuichi
Ishibashi, Ryoichi
Source
Case Reports in Ophthalmological Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-11-16
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Purpose.
Diabetic macular edema (DME) is a vision-threatening condition that develops in diabetic patients.
The first-line therapy for DME is intravitreal injections of antivascular endothelial growth factor (anti-VEGF) agents; however, the high frequency of repeat injections, invasiveness of the procedure, and high cost are drawbacks for this treatment.
The purpose of this report is to present our findings in 3 patients with chronic DME whose edema was resolved soon after oral doses of sodium-glucose cotransporter-2 (SGLT2) inhibitors were used.
Case Presentation.
Case 1 was a 66-year-old woman diagnosed with moderate nonproliferative diabetic retinopathy (DR) with DME that had developed a decade earlier.
The DME persisted for 4 years in the left eye.
The addition of oral empagliflozin, a SGLT2 inhibitor, led to a marked improvement of the DME after one month, and this improvement continued over two years.
Case 2 was a 68-year-old woman who was diagnosed with preproliferative DR with bilateral DME.
The addition of oral dapagliflozin led to the improvement of the DME after two months, and this improvement continued over one year.
Case 3 was a 61-year-old woman who was diagnosed with moderate nonproliferative DR with DME.
Oral luseogliflozin was given which led to better glycemic control, and her left central retinal thickness (CRT) was markedly reduced after only two weeks.
This reduction was maintained in her left eye for six months without any additional ophthalmic procedures.
Conclusions.
Although this study involved only three cases, our findings indicate that SGLT2 inhibitors might have possible efficacy for chronic DME.
American Psychological Association (APA)
Takatsuna, Yoko& Ishibashi, Ryoichi& Tatsumi, Tomoaki& Koshizaka, Masaya& Baba, Takayuki& Yamamoto, Shuichi…[et al.]. 2020. Sodium-Glucose Cotransporter 2 Inhibitors Improve Chronic Diabetic Macular Edema. Case Reports in Ophthalmological Medicine،Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1149711
Modern Language Association (MLA)
Takatsuna, Yoko…[et al.]. Sodium-Glucose Cotransporter 2 Inhibitors Improve Chronic Diabetic Macular Edema. Case Reports in Ophthalmological Medicine No. 2020 (2020), pp.1-6.
https://search.emarefa.net/detail/BIM-1149711
American Medical Association (AMA)
Takatsuna, Yoko& Ishibashi, Ryoichi& Tatsumi, Tomoaki& Koshizaka, Masaya& Baba, Takayuki& Yamamoto, Shuichi…[et al.]. Sodium-Glucose Cotransporter 2 Inhibitors Improve Chronic Diabetic Macular Edema. Case Reports in Ophthalmological Medicine. 2020. Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1149711
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1149711