Clinical Utility of Neutrophil CD64 to Detect Extrapulmonary Tuberculosis in Three Patients with Rheumatoid Arthritis Undergoing Treatment with Biologics
Joint Authors
Nogi, Shinichi
Arinuma, Yoshiyuki
Komiya, Akiko
Hashimoto, Atsushi
Matsui, Toshihiro
Tohma, Shigeto
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-12-06
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Biologics play a key role in the treatment of rheumatoid arthritis (RA), while RA-related serious infection remains an unsettled clinical problem.
Detection of tuberculosis (TB) is challenging due to the difficulty in distinguishing symptoms such as fever and elevation of inflammatory markers from other infections or a disease flare of RA.
The expression of the CD64 molecule on neutrophils (neutrophil CD64) was upregulated by various infections including TB.
However, it was not affected by disease activity of RA or by any therapy against RA.
The present article reports three cases of extrapulmonary TB which occurred in patients with RA undergoing treatment with biologics.
The marked increase in the levels of neutrophil CD64 may provide important insight into the diagnosis of TB.
American Psychological Association (APA)
Nogi, Shinichi& Arinuma, Yoshiyuki& Komiya, Akiko& Hashimoto, Atsushi& Matsui, Toshihiro& Tohma, Shigeto. 2018. Clinical Utility of Neutrophil CD64 to Detect Extrapulmonary Tuberculosis in Three Patients with Rheumatoid Arthritis Undergoing Treatment with Biologics. Case Reports in Rheumatology،Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1149789
Modern Language Association (MLA)
Nogi, Shinichi…[et al.]. Clinical Utility of Neutrophil CD64 to Detect Extrapulmonary Tuberculosis in Three Patients with Rheumatoid Arthritis Undergoing Treatment with Biologics. Case Reports in Rheumatology No. 2018 (2018), pp.1-6.
https://search.emarefa.net/detail/BIM-1149789
American Medical Association (AMA)
Nogi, Shinichi& Arinuma, Yoshiyuki& Komiya, Akiko& Hashimoto, Atsushi& Matsui, Toshihiro& Tohma, Shigeto. Clinical Utility of Neutrophil CD64 to Detect Extrapulmonary Tuberculosis in Three Patients with Rheumatoid Arthritis Undergoing Treatment with Biologics. Case Reports in Rheumatology. 2018. Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1149789
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1149789